For research and development scientists, the exploration of novel chemical pathways and the synthesis of complex molecules are at the heart of innovation. Understanding the properties and potential applications of chemical intermediates is crucial for designing effective synthetic routes. 5-Bromo-2,3-difluoroanisole, identified by CAS number 261762-35-0, is one such versatile intermediate that offers significant utility in synthetic organic chemistry.

Chemical Properties and Synthesis Potential

5-Bromo-2,3-difluoroanisole (C7H5BrF2O) is a halogenated aromatic compound that presents a unique combination of substituents on a benzene ring. The presence of two fluorine atoms and a bromine atom imparts specific electronic and steric properties, making it a valuable precursor for various chemical transformations.

  • Fluorine Substitution: The fluorine atoms enhance the molecule's electron-withdrawing nature, influencing the reactivity of the aromatic ring and adjacent functional groups. This can be beneficial for modulating the acidity, basicity, and overall electronic profile of synthesized compounds.
  • Bromine as a Leaving Group: The bromine atom serves as an excellent leaving group in nucleophilic substitution reactions and is a key participant in palladium-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings. These reactions are fundamental for carbon-carbon and carbon-heteroatom bond formation.
  • Methoxy Group: The methoxy group (-OCH3) provides a point of potential activation or derivatization and influences the compound's solubility in common organic solvents.

Applications in Research and Development

The multifaceted reactivity of 5-Bromo-2,3-difluoroanisole makes it a sought-after building block for several R&D applications:

  • Pharmaceutical Research: It is widely employed in the synthesis of novel drug candidates. Scientists can use it to introduce the difluoroanisole moiety into potential APIs, aiming to improve pharmacokinetic properties like metabolic stability, bioavailability, and target binding affinity. The ability to perform diverse coupling reactions allows for rapid library synthesis of related compounds for screening.
  • Agrochemical Development: Similar to pharmaceuticals, the fluorinated aromatic structure is beneficial in the design of new pesticides, herbicides, and fungicides. These modifications can enhance efficacy, selectivity, and environmental persistence profiles.
  • Materials Science: In some advanced materials research, such fluorinated aromatic compounds can serve as monomers or building blocks for specialized polymers or electronic materials where specific electronic or thermal properties are desired.

Sourcing for R&D Projects

For R&D scientists, readily accessing high-quality 5-Bromo-2,3-difluoroanisole is crucial for project momentum. When looking to buy 5-Bromo-2,3-difluoroanisole online, it's important to consider suppliers who provide detailed product specifications and reliable availability. As a key CAS 261762-35-0 chemical intermediate, partnering with an experienced 5-Bromo-2,3-difluoroanisole manufacturer, especially one with a strong presence in China, ensures access to competitive pricing and consistent product quality. This allows researchers to efficiently obtain the quantities needed for experimental work, from milligram-scale testing to gram-scale synthesis without compromising project timelines or budgets. Always verify the purity and seek comprehensive technical data to ensure the intermediate meets your specific research needs.