In the relentless pursuit of novel therapeutics, the role of specialized chemical intermediates cannot be overstated. 5-Bromo-2-fluorobenzotrifluoride (CAS: 393-37-3) stands out as a cornerstone building block for pharmaceutical research and development. Its unique trifluoromethylated and halogenated aromatic structure provides chemists with a powerful tool for constructing complex molecular architectures that exhibit enhanced pharmacological properties.

Understanding the Chemical Profile
5-Bromo-2-fluorobenzotrifluoride, with the molecular formula C7H3BrF4, is a colorless liquid characterized by a density of approximately 1.72 g/mL and a boiling point around 179-180°C at 50 mm Hg. The presence of the trifluoromethyl (CF3) group is particularly significant, as it is known to increase the lipophilicity and metabolic stability of drug candidates, thereby improving their bioavailability and efficacy. The bromine atom serves as an excellent leaving group for various cross-coupling reactions, while the fluorine atom contributes to the electronic properties of the aromatic ring, influencing reactivity and biological interactions.

Synthetic Utility and Applications
The primary application of 5-Bromo-2-fluorobenzotrifluoride lies in its use as a pharmaceutical intermediate. It is widely employed in the synthesis of Active Pharmaceutical Ingredients (APIs) for a broad spectrum of therapeutic areas. Its reactive nature allows for facile introduction into complex molecular frameworks via reactions such as:

  • Palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Stille, Heck): These reactions enable the formation of carbon-carbon bonds, essential for building intricate organic scaffolds.
  • Nucleophilic aromatic substitution: The fluorine atom can be involved in substitution reactions, further diversifying the possible synthetic routes.
  • Directed metallation: The substituents can direct lithiation or Grignard formation, allowing for regioselective functionalization.

Beyond pharmaceuticals, this compound also finds application in the development of agrochemicals and advanced materials due to its unique chemical properties.

Procuring from Reliable Suppliers
For R&D scientists and purchasing managers, sourcing 5-Bromo-2-fluorobenzotrifluoride from a dependable manufacturer is critical. China has emerged as a leading global supplier of fine chemicals, offering high-purity intermediates at competitive prices. When looking to buy this crucial compound, prioritize suppliers who can demonstrate a strong commitment to quality control, provide detailed product specifications, and offer reliable delivery. Engaging with an experienced chemical supplier in China can streamline your procurement process and ensure you receive materials that meet the rigorous demands of pharmaceutical synthesis.

If your research demands high-quality 5-Bromo-2-fluorobenzotrifluoride, consider partnering with established chemical manufacturers in China. Their expertise in synthesis and production can be instrumental in your efforts to bring innovative medicines to market.