When sourcing chemical intermediates for pharmaceutical applications, meticulous attention to specifications and quality is non-negotiable. 5-Bromoindole (CAS 10075-50-0) is a prime example of such a critical compound, widely employed in the synthesis of active pharmaceutical ingredients (APIs). Understanding its typical properties and required quality standards is essential for procurement specialists and R&D scientists alike, ensuring that their purchasing decisions from manufacturers and suppliers are informed and effective.

The core specifications for 5-Bromoindole typically revolve around its physical appearance, purity, and certain chemical properties. As a standard, it is described as an off-white to white powder. This visual characteristic is the first indicator of material quality. Purity, most commonly assessed by High-Performance Liquid Chromatography (HPLC), is a paramount metric. For pharmaceutical intermediate use, purity levels of not less than 99.0% are often required, with single maximum impurities strictly controlled (e.g., not more than 0.50%). Ensuring this high purity is what makes 5-Bromoindole a reliable building block for complex syntheses.

Beyond purity, other typical properties provide crucial insights for chemists. Solubility, for instance, noting it is freely soluble in methanol, aids in selecting appropriate reaction solvents. The melting range, usually specified between 88°C to 92°C, serves as another indicator of purity and batch consistency. Parameters such as Loss on Drying (LOD), typically limited to 0.5% w/w, and Water Content (by Karl Fischer titration), usually not more than 0.2%, are also critical for maintaining reaction integrity and accurate weighing.

For companies looking to buy 5-Bromoindole, partnering with a reputable manufacturer that adheres to strict quality control protocols is vital. Such suppliers will provide comprehensive documentation, including Certificates of Analysis (CoA) for each batch, detailing all relevant specifications. This transparency is crucial for regulatory compliance and for building confidence in the material's suitability for pharmaceutical synthesis.

When evaluating a 5-Bromoindole supplier, inquire about their quality management systems and their ability to consistently meet these rigorous specifications. The investment in high-quality 5-Bromoindole (CAS 10075-50-0) from a trusted manufacturer directly translates to more predictable synthesis outcomes, reduced rework, and ultimately, more efficient drug development. Therefore, a thorough understanding of these specifications is key to making informed purchase decisions in the competitive landscape of pharmaceutical intermediates.