For chemists and researchers involved in organic synthesis, understanding the precise technical specifications and versatile applications of chemical intermediates is fundamental to successful project execution. 5-Bromopyrimidine (CAS 4595-59-9) is a key heterocyclic compound that offers a rich chemistry, making it indispensable across various sectors. NINGBO INNO PHARMCHEM CO.,LTD. provides detailed information for those looking to buy 5-Bromopyrimidine.

Technical Profile of 5-Bromopyrimidine

Chemical Name: 5-Bromopyrimidine
CAS Number: 4595-59-9
Molecular Formula: C4H3BrN2
Molecular Weight: 158.98 g/mol
Appearance: Typically a yellow to beige-brown crystalline powder or chunks.
Melting Point: 67-73 °C (literature value)
Purity: Generally available at high purities, often ≥98% (GC or HPLC), crucial for demanding synthetic routes.

The chemical structure of 5-Bromopyrimidine features a pyrimidine ring with a bromine atom at the 5-position. This bromine atom is particularly reactive, making it an excellent leaving group in nucleophilic substitution reactions and a key participant in various metal-catalyzed cross-coupling reactions, such as Suzuki, Sonogashira, and Heck couplings. These reactions allow for the efficient construction of complex carbon frameworks and the introduction of diverse functionalities.

Key Applications Across Industries

  • Pharmaceutical Synthesis: 5-Bromopyrimidine serves as a critical intermediate in the synthesis of numerous Active Pharmaceutical Ingredients (APIs). It is instrumental in developing drugs for antiviral, anticancer, and kinase inhibitor therapies. Its role in building complex heterocyclic scaffolds makes it highly sought after by the pharmaceutical R&D sector.
  • Agrochemicals: In the agrochemical industry, this compound is utilized for the synthesis of herbicides and fungicides. Its reactivity facilitates the creation of new molecules with enhanced efficacy and targeted action for crop protection.
  • Advanced Materials: Material scientists employ 5-Bromopyrimidine as a building block for functionalized ligands, organic electronic materials, and polymers, contributing to advancements in fields like optoelectronics and catalysis.

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