In the intricate world of organic chemistry, certain molecules stand out for their versatility and utility as building blocks for more complex structures. 5-Chlorothiophene-2-sulfonyl chloride, identified by CAS number 2766-74-7, is one such compound. Its unique chemical features make it a highly sought-after intermediate in various sectors, particularly in the pharmaceutical and agrochemical industries. Understanding its synthetic potential is key for researchers and formulators looking to innovate.

The Chemical Profile of 5-Chlorothiophene-2-sulfonyl Chloride

As a derivative of thiophene, 5-chlorothiophene-2-sulfonyl chloride integrates a sulfur-containing heterocyclic ring with a reactive sulfonyl chloride functional group. This combination imparts specific chemical properties that are highly advantageous in synthesis:

  • Reactivity: The sulfonyl chloride moiety (-SO2Cl) is an excellent electrophile, readily undergoing reactions with nucleophiles such as amines, alcohols, and thiols. This makes it ideal for forming sulfonamides, sulfonates, and sulfones, respectively.
  • Thiophene Ring: The thiophene ring itself can participate in various electrophilic aromatic substitution reactions, and its presence often confers desirable pharmacokinetic properties or specific electronic characteristics to the final molecule.
  • Chlorine Substitution: The chlorine atom on the thiophene ring can influence the electronic distribution and reactivity of the molecule, potentially directing further reactions or modifying the properties of the synthesized product.

The compound is typically supplied as a solid with a purity of at least 95%, ensuring good results in demanding synthetic protocols. Researchers often seek this compound from established manufacturers to guarantee quality and consistency.

Applications Driving Demand

The demand for 5-chlorothiophene-2-sulfonyl chloride is driven by its critical role in synthesizing molecules with significant commercial and scientific value:

Pharmaceutical Development: This intermediate is crucial for synthesizing numerous drug candidates and active pharmaceutical ingredients (APIs). Many modern pharmaceuticals incorporate heterocyclic rings like thiophene due to their favorable biological activities and metabolic profiles. The sulfonyl chloride group allows for the straightforward introduction of sulfonamide linkages, which are common in many drug classes, including antibiotics and diuretics.

Agrochemical Innovation: In the agrochemical sector, thiophene derivatives are frequently used in the design of pesticides, herbicides, and fungicides. The incorporation of this sulfonyl chloride allows for the creation of molecules with targeted efficacy and potentially improved environmental profiles. Companies actively developing new crop protection agents will often buy this compound for their formulation research.

Material Science: Beyond life sciences, thiophene-based compounds are explored for their electronic and optical properties, making them relevant in the development of organic semiconductors, conducting polymers, and other advanced materials. 5-Chlorothiophene-2-sulfonyl chloride can serve as a precursor for such specialized applications.

Where to Buy

For scientists and procurement specialists, sourcing high-quality 5-chlorothiophene-2-sulfonyl chloride is essential. Reputable manufacturers, particularly those based in China, offer this chemical with detailed specifications and reliable supply chains. When seeking to buy this intermediate, it is advisable to engage with suppliers who can provide consistent purity and timely delivery. Comparative pricing from various suppliers can help in securing a cost-effective solution for research and development projects.

In summary, 5-chlorothiophene-2-sulfonyl chloride (CAS 2766-74-7) is a vital component in the toolkit of synthetic chemists. Its broad applicability across pharmaceuticals, agrochemicals, and material science underscores its importance in chemical innovation. For those looking to purchase this compound, focusing on trusted suppliers who can ensure quality and availability is key to unlocking its full synthetic potential.