The pharmaceutical industry relies on a vast array of specialized chemical intermediates to synthesize life-saving medications. Among these essential compounds, 5-Fluorooxindole (CAS 56341-41-4) holds significant importance. This fluorinated heterocyclic compound serves as a vital building block, most notably in the production of targeted cancer therapies. For researchers and manufacturing professionals, understanding its properties, synthesis, and reliable sourcing is crucial.

Chemical Profile of 5-Fluorooxindole

Chemical Name: 5-Fluoro-2-oxindole CAS Number: 56341-41-4 Molecular Formula: C8H6FNO Molecular Weight: 151.14 g/mol Appearance: Typically an off-white to pale brown or beige crystalline powder. Purity: Commonly available at >98% purity.

The structure of 5-Fluorooxindole combines an oxindole core with a fluorine atom. This fluorination often enhances a molecule's pharmacokinetic properties, such as increased lipophilicity and metabolic stability, making it highly valuable in drug design. The oxindole moiety itself is a common feature in many biologically active natural products and synthetic drugs.

Synthesis of 5-Fluorooxindole

The preparation of 5-Fluorooxindole typically involves a multi-step synthesis starting from readily available precursors. A common route involves:

  1. Starting with 4-fluoroaniline, which is reacted with chloral hydrate and hydroxylamine hydrochloride to form 4-fluoroisonitrosoacetanilide.
  2. Subsequent cyclization of this intermediate under acidic conditions (e.g., concentrated sulfuric acid) yields 5-fluoroisatin.
  3. Finally, a reduction step, often using a Wolff-Kishner-Huang minlon reduction or similar methods, converts 5-fluoroisatin to 5-Fluorooxindole.

This synthetic pathway ensures the production of a high-purity intermediate crucial for downstream pharmaceutical applications. Manufacturers continuously optimize these processes for yield and efficiency.

Key Applications in Pharmaceuticals

The most prominent application of 5-Fluorooxindole is its role as a key intermediate in the synthesis of Sunitinib. Sunitinib is an oral, multi-targeted receptor tyrosine kinase inhibitor used to treat several types of cancer, including renal cell carcinoma and gastrointestinal stromal tumors. The development of such targeted therapies relies heavily on the availability of high-quality building blocks like 5-Fluorooxindole. Beyond Sunitinib, this compound is also utilized as a reagent in the synthesis of other potential drug candidates, including inhibitors for various enzymes and signaling pathways critical in disease progression. Its unique fluorinated heterocyclic structure makes it an attractive scaffold for medicinal chemists exploring new therapeutic avenues.

Where to Buy 5-Fluorooxindole

For pharmaceutical manufacturers and research institutions, sourcing 5-Fluorooxindole from reputable suppliers is paramount. When looking to buy this essential intermediate, it is advisable to partner with experienced chemical manufacturers and suppliers. These suppliers typically offer:

  • High-purity material (>98%)
  • Detailed product specifications and Certificates of Analysis (CoA)
  • Bulk packaging options (e.g., 25KG drums) for large-scale production
  • Competitive pricing and responsive customer service

As a leading manufacturer and supplier in China, we are dedicated to providing high-quality 5-Fluorooxindole to meet the stringent demands of the pharmaceutical industry. We offer reliable sourcing solutions, competitive pricing, and comprehensive technical support to facilitate your drug development and manufacturing processes. If your organization requires a dependable source for 5-Fluorooxindole, please contact us to discuss your procurement needs and to obtain a quotation.