In the intricate world of molecular biology, techniques that allow precise manipulation and study of biomolecules are invaluable. Photoactivated cross-linking, a method that uses light to covalently link molecules, is one such powerful tool. Central to many of these studies is the use of specially modified nucleosides, like 5-Iodo-2'-deoxycytidine (CAS 611-53-0). As a manufacturer and supplier of high-quality biochemicals, we highlight the significance of this compound in enabling such advanced research methodologies.

5-Iodo-2'-deoxycytidine is a synthetic analog of the natural nucleoside deoxycytidine. Its key feature, the iodine atom at the 5-position, makes it highly suitable for incorporation into DNA oligomers intended for photoactivated cross-linking experiments. When irradiated with specific wavelengths of light, the carbon-iodine bond can undergo homolytic cleavage, generating reactive radical species. These radicals can then efficiently form covalent bonds with neighboring molecules, such as proteins or other nucleic acid strands, effectively 'freezing' molecular complexes in place.

This capability is crucial for studying transient molecular interactions within cells, determining the binding sites of proteins to DNA, and mapping the structure of complex macromolecular assemblies. By precisely controlling the irradiation, researchers can achieve site-specific labeling and cross-linking, providing high-resolution data that is otherwise difficult to obtain. The ability to buy 5-Iodo-2'-deoxycytidine of high purity (≥99.0%) from reliable manufacturers ensures that these critical experiments yield meaningful and accurate results.

The synthesis of DNA oligomers for these applications requires reagents of exceptional quality to guarantee successful incorporation and efficient cross-linking. Our role as a manufacturer is to provide researchers with the confidence that the 5-Iodo-2'-deoxycytidine they purchase will perform consistently. We understand the demands of such specialized research and are committed to supplying a product that meets rigorous purity standards. For those looking to buy this vital reagent, partnering with a dependable supplier like us means securing a material that supports the precision required for photoactivated cross-linking studies.

We encourage researchers and procurement teams to consider our offerings for their DNA modification and cross-linking needs. With our high-purity 5-Iodo-2'-deoxycytidine, you can confidently advance your research projects. Contact us to learn more about our product specifications, pricing, and how we can support your laboratory's supply requirements as a leading chemical manufacturer.