For R&D scientists and pharmaceutical chemists, understanding the fundamental properties and synthesis of key intermediates is crucial for innovation and efficient production. 6-Aminouracil (CAS 873-83-6) stands out as a significant compound within the realm of pharmaceutical intermediates. Its chemical versatility and high purity make it indispensable for several critical API manufacturing processes.

Chemical Profile of 6-Aminouracil

6-Aminouracil, also known by its IUPAC name 6-amino-1H-pyrimidine-2,4-dione, is characterized by its molecular formula C4H5N3O2 and a molecular weight of 127.10. It typically appears as a yellowish crystalline powder with a melting point exceeding 360°C, indicating its thermal stability. Its solubility is noted as slight in water and methanol, but it can be soluble in heated DMSO.

Key physico-chemical properties include:

  • Appearance: Yellowish crystalline powder
  • Purity: Typically ≥99%
  • CAS Number: 873-83-6
  • Molecular Formula: C4H5N3O2
  • Solubility: Slightly soluble in water and methanol

Synthesis and Manufacturing Insights

While various synthesis routes exist, a common method involves reacting ethyl cyanoacetate with urea or related compounds in the presence of a base like sodium ethoxide, followed by acidification and purification. For companies looking to buy this intermediate, understanding the synthesis process can provide insights into potential impurity profiles and quality control measures. Reliable manufacturers often refine these processes to achieve high yields and purity, ensuring a dependable product for downstream applications.

Critical Role in Pharmaceutical Synthesis

The significance of 6-Aminouracil is most evident in its applications:

  • Intermediate for Caffeine: It's a cornerstone in the multi-step synthesis of caffeine, a stimulant and active ingredient in numerous pharmaceuticals and consumer products.
  • Intermediate for Theophylline: This compound is also essential for manufacturing theophylline, a xanthine derivative used as a bronchodilator in treating respiratory ailments.
  • R&D Applications: Its specific chemical structure makes it a valuable starting material for researchers developing new drugs and exploring novel chemical entities within the pyrimidine class.

Procurement Considerations for R&D Professionals

When sourcing 6-Aminouracil for research and development, scientists must prioritize purity and reliable availability. Partnering with a reputable supplier, particularly one that can offer detailed technical data and consistent batch quality, is crucial. For those seeking to purchase in bulk or for specific research projects, exploring options from established manufacturers in China can provide access to high-grade materials at competitive prices.

In summary, 6-Aminouracil (CAS 873-83-6) is more than just a chemical compound; it's a critical enabler for pharmaceutical innovation. Its properties and synthetic utility solidify its position as a key intermediate. Understanding its profile empowers R&D professionals to make informed decisions when sourcing from global suppliers.