In the intricate world of chemical synthesis, the availability of versatile and well-characterized building blocks is paramount. 6-Chloronicotinic Acid (CAS 5326-23-8) stands out as a prime example of such a compound. This heterocyclic chemical, belonging to the pyridine family, offers a unique combination of functional groups that make it an indispensable intermediate for a wide array of applications, particularly in the pharmaceutical and agrochemical sectors.

Understanding the Chemical Profile of 6-Chloronicotinic Acid

With the molecular formula C6H4ClNO2 and a molecular weight of 157.55, 6-Chloronicotinic Acid presents itself typically as an off-white to beige crystalline powder. Its structure features a pyridine ring substituted with a chlorine atom at the 6-position and a carboxylic acid group at the 3-position. This specific arrangement of functional groups imparts distinct reactivity, making it a valuable precursor in complex organic synthesis pathways. The presence of the chlorine atom allows for nucleophilic substitution reactions, while the carboxylic acid group can undergo esterification, amidation, or decarboxylation, offering chemists a flexible platform for molecular design.

Key Applications in Chemical Synthesis

The significance of 6-Chloronicotinic Acid is most pronounced in its role as a pharmaceutical intermediate. It is a critical component in the synthesis of molecules designed to act as targeted inhibitors. For instance, it's a building block for BRAFV600E inhibitors, crucial in oncology research, and also for novel DNA-gyrase B inhibitors, important in antimicrobial drug development. Beyond pharmaceuticals, its utility extends to agrochemical synthesis, where it can be incorporated into the structure of pesticides or herbicides. Researchers often buy this chemical for its reliability and the predictability of its reactions, facilitating efficient process development.

Sourcing and Quality Considerations for Buyers

For scientists and procurement specialists looking to buy 6-Chloronicotinic Acid, partnering with reputable manufacturers and suppliers is essential. Companies specializing in fine chemicals and pharmaceutical intermediates, especially those based in China, offer high-purity grades (e.g., >97%) of this compound. When evaluating suppliers, attention should be paid to their production capabilities, quality control measures, and ability to provide comprehensive documentation such as Certificates of Analysis. Understanding the product's physical properties, such as its melting point (around 190°C) and solubility, is also important for effective handling and reaction planning. Accessing this versatile building block reliably ensures the progression of innovative research and product development.