For chemists engaged in the synthesis of fine chemicals, pharmaceuticals, and advanced materials, understanding the properties and reactivity of key intermediates is fundamental. 6-Iodo-1-Hexanol, identified by its CAS number 40145-10-6 and chemical formula C6H13IO, is a highly valuable bifunctional molecule that bridges basic chemical feedstocks to complex end products. Its utility in organic synthesis is derived from the presence of both a primary alcohol and a terminal alkyl iodide.

Physically, 6-Iodo-1-Hexanol is typically described as a yellow to red liquid, with a characteristic odor. Its solubility profile generally favors organic solvents such as alcohols, ethers, and chlorinated hydrocarbons, while exhibiting limited solubility in water. This characteristic is often advantageous for reaction work-ups and purifications in common organic synthesis protocols.

The chemical reactivity of 6-Iodo-1-Hexanol is dictated by its two functional groups. The primary alcohol group (-OH) can undergo standard alcohol transformations. It can be esterified by reacting with carboxylic acids or acid derivatives, or etherified via reactions like the Williamson ether synthesis. Furthermore, it can be oxidized to an aldehyde or a carboxylic acid, depending on the oxidizing agent and conditions employed.

The terminal alkyl iodide (-CH2I) is perhaps the more significant functional group in terms of synthetic versatility. The carbon-iodine bond is polarized and the iodide ion is an excellent leaving group. This makes the carbon atom highly susceptible to nucleophilic attack, facilitating a wide range of SN2 reactions. For example, reacting 6-Iodo-1-Hexanol with various nucleophiles can lead to the formation of new carbon-heteroatom bonds (e.g., C-N, C-O, C-S) or carbon-carbon bonds via organometallic intermediates or cyanide displacement.

The compound is also a valuable precursor for forming organometallic reagents. Treatment with magnesium can yield the corresponding Grignard reagent, while reaction with organolithium reagents can form organolithium species. These reagents are powerful nucleophiles and are instrumental in forming new carbon-carbon bonds, a cornerstone of organic synthesis.

When considering the procurement of this essential chemical, understanding the CAS 40145-10-6 price in relation to its quality is vital. Reputable 6-iodo-1-hexanol manufacturers will ensure high purity, often exceeding 98.0%, which is crucial for demanding synthetic pathways, particularly in pharmaceutical and agrochemical development. Accessing these materials often involves engaging with specialized chemical suppliers.

Safety in handling is a critical aspect of working with any chemical. 6-Iodo-1-Hexanol, like many organic iodides, should be handled with care. It is recommended to wear appropriate personal protective equipment (PPE), including chemical-resistant gloves, safety goggles, and lab coats. Operations should be conducted in a well-ventilated area, preferably a fume hood, to minimize inhalation of vapors. Storage recommendations typically include keeping the compound in a tightly sealed container in a cool, dry, and well-ventilated place, away from strong oxidizing agents, heat, and direct sunlight.

For those looking to integrate 6-Iodo-1-Hexanol into their synthesis, sourcing from a trusted 6-iodo-1-hexanol supplier in China or elsewhere offers benefits in terms of consistent quality and supply reliability. Always request a Certificate of Analysis to confirm product specifications and consider obtaining a 6-iodo-1-hexanol manufacturer quote for bulk orders to ensure cost-effectiveness.

In essence, 6-Iodo-1-Hexanol is a workhorse intermediate in organic synthesis, offering a unique combination of reactivity. Its properties and the ability to perform diverse chemical transformations make it an indispensable tool for chemists aiming to create innovative molecules.