For researchers in pharmacology, endocrinology, and natural product chemistry, 8-Prenylnaringenin (CAS 53846-50-7) stands out as a compound of significant interest. This potent prenylflavonoid phytoestrogen, primarily derived from hops (Humulus lupulus), exhibits remarkable biological activities that make it a valuable tool for scientific investigation.

Understanding the Chemical Profile of 8-Prenylnaringenin

8-Prenylnaringenin is characterized by its flavonoid structure with a prenyl side chain. Its molecular formula is C20H20O5, and it typically appears as a white solid. The compound's most notable feature is its potent estrogenic activity, often reported as being stronger than other known phytoestrogens like genistein or daidzein. This activity stems from its ability to bind to and activate both estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ), with a particular affinity for ERα. This mechanism allows it to mimic or modulate the effects of endogenous estrogens.

Key Research Applications: A Phytoestrogen with Broad Potential

The unique properties of 8-Prenylnaringenin lend themselves to a variety of research applications:

  • Hormone Research: As a potent ER agonist, 8-Prenylnaringenin is invaluable for studying estrogenic pathways. Researchers use it to investigate the effects of estrogen modulation on various physiological processes, including bone density preservation, cardiovascular health, and reproductive functions. Its use in studying menopausal symptoms, such as hot flashes, is a prominent area of research.
  • Pharmaceutical Intermediate: The compound serves as a crucial pharmaceutical intermediate for the development of novel therapeutic agents. Its structural features and biological activity make it a promising scaffold for drugs targeting hormone-related disorders, menopausal complaints, and potentially certain types of hormone-sensitive cancers. When you buy 8-Prenylnaringenin from a reputable manufacturer, you ensure the quality needed for pharmaceutical synthesis.
  • Anticancer Research: Emerging studies suggest that 8-Prenylnaringenin may possess anticancer properties. Its ability to influence cell proliferation and apoptosis in various cancer cell lines is an active area of investigation. Researchers are exploring its potential as a chemopreventive agent or as a component in combination cancer therapies.
  • Metabolic Research: Preliminary research indicates that 8-Prenylnaringenin may play a role in regulating metabolic pathways, potentially influencing glucose and lipid metabolism. This opens avenues for exploring its application in managing metabolic disorders like diabetes.
  • Neuroscience: Some studies have explored the neurodifferentiating potential of 8-Prenylnaringenin and its related compounds, suggesting possible applications in regenerative medicine for neurological conditions.

Sourcing High-Quality 8-Prenylnaringenin

For researchers requiring this compound, it is essential to source 8-Prenylnaringenin from reliable suppliers and manufacturers who guarantee high purity and consistent quality. Companies offering this product often specialize in natural products, pharmaceutical intermediates, and research chemicals. When considering purchase options, always inquire about the CAS number (53846-50-7) and the provided analytical data to ensure it meets your research requirements.

In conclusion, 8-Prenylnaringenin is a scientifically significant compound with a wide range of current and potential applications. Its potent estrogenic activity, coupled with emerging research into other biological effects, makes it an indispensable tool for researchers in various fields. As a dedicated supplier, we are committed to providing researchers with access to this vital phytoestrogen, supporting their groundbreaking discoveries.