For pharmaceutical researchers and procurement specialists, the consistent availability of high-purity intermediates is non-negotiable. 9-Anthraldehyde, identified by its CAS number 642-31-9, is a pivotal organic intermediate extensively utilized in the synthesis of Active Pharmaceutical Ingredients (APIs). This guide provides essential information on its properties, applications, and the most effective strategies for sourcing this compound from reputable manufacturers and suppliers.

Understanding 9-Anthraldehyde for Pharmaceutical Applications

9-Anthraldehyde is characterized by its yellow crystalline powder form, a melting point of 103-105°C, and good solubility in solvents like toluene. With the molecular formula C15H10O and a molecular weight of 206.24 g/mol, its anthracene core provides a unique structural scaffold for drug development. Pharmaceutical-grade 9-Anthraldehyde typically exhibits high purity, often specified as ≥98% or ≥99% (HPLC), which is critical for ensuring the efficacy and safety of synthesized APIs. While generally stable, it requires protection from light, air, and moisture, and should be stored in cool, dry conditions to maintain its integrity.

Critical Role in API Synthesis

The value of 9-Anthraldehyde in the pharmaceutical sector stems from its versatility as a synthetic intermediate. It is employed in several key processes:

  • API Synthesis: It serves as a foundational building block in multi-step synthetic routes for various therapeutic compounds, enabling the introduction of specific functional groups and structural motifs necessary for pharmacological activity.
  • Ligand Preparation: Researchers use 9-Anthraldehyde to prepare specialized ligands, which can be crucial in catalytic processes for pharmaceutical synthesis.
  • Organic Synthesis: Its participation in reactions like the Diels-Alder reaction makes it a valuable tool for constructing complex molecular architectures, which are often found in novel drug candidates.

Procurement Best Practices for R&D and Manufacturing

When looking to buy 9-Anthraldehyde for pharmaceutical research and development or manufacturing, it is paramount to partner with trusted chemical suppliers and manufacturers, especially those with expertise in fine chemicals and intermediates. Key considerations for procurement include:

  • Purity and Quality Assurance: Always verify that the supplied CAS 642-31-9 meets the stringent purity requirements for pharmaceutical applications, supported by Certificates of Analysis (CoA).
  • Supplier Reliability: Choose suppliers with a proven track record in the pharmaceutical supply chain, ensuring consistent batch-to-batch quality and timely deliveries.
  • Competitive Pricing: Obtain detailed quotes from multiple vendors to secure the best possible price, particularly for larger R&D or production volumes.
  • Regulatory Compliance: Ensure your supplier adheres to relevant industry regulations and quality management standards.

For pharmaceutical companies, engaging with suppliers like NINGBO INNO PHARMCHEM CO.,LTD. provides access to high-quality intermediates backed by technical expertise and a commitment to customer service. By following these procurement guidelines, pharmaceutical professionals can ensure a secure and efficient supply of 9-Anthraldehyde for their critical synthetic needs.