In the realm of advanced organic synthesis, the creation of complex molecules hinges on the availability of versatile and reactive building blocks. Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate (CAS 372198-69-1) emerges as a critical intermediate, offering chemists a powerful tool for constructing novel compounds with significant biological relevance.

NINGBO INNO PHARMCHEM CO.,LTD., a distinguished B2B chemical manufacturer and supplier from China, specializes in providing such high-quality reagents. We offer Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate, ensuring its suitability for demanding synthetic applications and making it accessible for researchers worldwide.

Chemical Reactivity and Synthetic Potential

The structural features of Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate endow it with rich chemical reactivity, making it a cornerstone for diverse synthetic strategies:

  • Substitution Reactions: The bromine atom at the 6-position is amenable to various nucleophilic substitution reactions, including palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig couplings). These reactions are invaluable for introducing a wide array of aryl, heteroaryl, alkyl, or amine substituents, thereby expanding molecular complexity.
  • Ester Functionalization: The ethyl carboxylate group at the 3-position can undergo standard ester transformations, such as hydrolysis to the corresponding carboxylic acid, reduction to an alcohol, or reaction with organometallic reagents to form ketones or tertiary alcohols. These modifications allow for further fine-tuning of molecular properties.
  • Heterocyclic Core Reactivity: The imidazo[1,2-a]pyridine scaffold itself can participate in electrophilic aromatic substitution under specific conditions, though typically less reactive than the bromine moiety.

Applications in Drug Discovery and Beyond

The synthetic versatility of Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate directly translates into its broad applicability:

  • Pharmaceutical Intermediates: It is a vital precursor in the synthesis of compounds with potential therapeutic value, such as novel antimycobacterial agents and inhibitors of critical signaling pathways like PI3K, important in cancer research.
  • Material Science: Derivatives might find applications in the development of organic electronic materials or functional dyes, owing to the conjugated pi-system of the heterocyclic core.
  • Agrochemical Research: Modified structures could potentially exhibit bioactivity suitable for agricultural applications.

Sourcing from a Reliable China Manufacturer

NINGBO INNO PHARMCHEM CO.,LTD. is committed to supplying Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate that meets rigorous standards for purity (≥98.20% HPLC) and consistency. By sourcing directly from us, you benefit from competitive pricing, dependable lead times, and direct access to a specialist manufacturer. We cater to various scales, from laboratory research to industrial production, ensuring your synthetic needs are met efficiently.

Request Your Quote Today

For chemists and procurement professionals engaged in advanced organic synthesis, securing a high-quality supply of Ethyl 6-bromoimidazo[1,2-a]pyridine-3-carboxylate is essential. Contact NINGBO INNO PHARMCHEM CO.,LTD. to obtain a quotation and discuss how our expertise and product offerings can support your synthetic challenges. Purchase with confidence from a leading Chinese supplier.