Advanced Synthesis with 3,5-Bis(methoxycarbonyl)phenylboronic Acid: A Chemist's Guide
For the modern organic chemist, the availability of versatile and reliable building blocks is fundamental to pushing the boundaries of molecular synthesis. 3,5-Bis(methoxycarbonyl)phenylboronic Acid (CAS: 177735-55-6) represents such a valuable intermediate, offering a unique combination of a phenylboronic acid moiety with ester functionalities, enabling a wide array of transformations. Sourcing this compound from a quality manufacturer, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures you have a dependable component for your most demanding synthetic challenges.
The cornerstone of 3,5-Bis(methoxycarbonyl)phenylboronic Acid's utility lies in its participation in palladium-catalyzed cross-coupling reactions, most notably the Suzuki-Miyaura coupling. This reaction is a powerful tool for forging carbon-carbon bonds, a critical step in constructing complex organic frameworks found in pharmaceuticals, agrochemicals, and advanced materials. The boronic acid group (-B(OH)2) readily engages with aryl or vinyl halides or pseudohalides in the presence of a palladium catalyst and a base. The two methoxycarbonyl groups (-COOCH3) present on the phenyl ring can influence the regioselectivity and reactivity, allowing for fine-tuning of the reaction outcome.
Chemists looking to buy 3,5-Bis(methoxycarbonyl)phenylboronic Acid will find its structure particularly beneficial for synthesizing derivatives with ester functionalities. These can either be retained in the final product to impart specific properties (e.g., solubility, reactivity) or be further transformed through hydrolysis, reduction, or amidation. For example, its application in the synthesis of 3,4-disubstituted coumarins highlights its capability in forming complex heterocyclic systems efficiently. This makes it an attractive option for researchers aiming to build libraries of compounds for drug discovery or materials science exploration.
When considering the use of this intermediate in your laboratory, it is vital to secure a source that provides consistent quality. A high purity level (typically 97%+) is essential to prevent side reactions and ensure good yields. Collaborating with a trusted manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. means you can access this high-grade chemical intermediate at competitive prices, backed by a commitment to quality control. This allows you to focus on the chemistry, confident in the reliability of your starting materials.
In summary, 3,5-Bis(methoxycarbonyl)phenylboronic Acid is a potent tool in the synthetic chemist's arsenal. Its robust reactivity in cross-coupling reactions and the presence of versatile ester groups make it an indispensable intermediate for advanced organic synthesis. Engage with reliable suppliers to ensure your research progresses smoothly and efficiently.
Perspectives & Insights
Silicon Analyst 88
“The two methoxycarbonyl groups (-COOCH3) present on the phenyl ring can influence the regioselectivity and reactivity, allowing for fine-tuning of the reaction outcome.”
Quantum Seeker Pro
“Chemists looking to buy 3,5-Bis(methoxycarbonyl)phenylboronic Acid will find its structure particularly beneficial for synthesizing derivatives with ester functionalities.”
Bio Reader 7
“These can either be retained in the final product to impart specific properties (e.”