All-trans-Retinol (CAS 68-26-8), a key isomer of Vitamin A, is a molecule celebrated for its profound biological activities and versatility across various industries. Its significance extends from fundamental biological processes to sophisticated formulation science. For chemists, formulators, and procurement specialists, understanding the technical specifications and sourcing strategies for high-purity all-trans-Retinol is essential for developing innovative and effective products.

Chemically, all-trans-Retinol is a diterpene, characterized by its specific stereochemistry that dictates its biological activity. Its molecular formula is C20H30O, with a molecular weight of approximately 286.45 g/mol. The compound typically appears as a yellow to orange powder and is sensitive to light and air, necessitating careful handling and storage. Its solubility in organic solvents like ethanol, methanol, and chloroform, and limited solubility in water, are critical considerations for formulation development.

The primary applications of all-trans-Retinol span critical sectors:

  • Pharmaceuticals: Used as an active pharmaceutical ingredient (API) or intermediate, it’s integral in formulations designed to address Vitamin A deficiencies, support vision health, and contribute to immune system strength. Pharmaceutical buyers often seek suppliers offering pharmaceutical grade vitamin A with assays of 99.5% or higher, adhering to USP, BP, and EP standards.
  • Cosmetics: Renowned for its anti-aging and skin-renewal properties, all-trans-Retinol is a premium ingredient in high-performance skincare. Formulators value its ability to improve skin texture, reduce wrinkles, and enhance skin radiance. Sourcing quality cosmetic grade retinol is key to product efficacy.
  • Animal Feed: As a vital feed additive, it ensures proper growth, vision, and immune response in livestock. Ensuring consistent quality from a dedicated feed additive manufacturer is crucial for animal health and farm productivity.

When sourcing all-trans-Retinol, partnering with a specialized manufacturer is advantageous. A global all-trans-Retinol supplier based in China can offer competitive pricing and a stable supply chain, backed by robust quality assurance systems. This allows businesses to purchase all-trans-Retinol efficiently, ensuring product integrity for their formulations.

For formulators, understanding the stability profile of all-trans-Retinol is key. It can be prone to oxidation, which can degrade its efficacy. Therefore, suppliers who offer stable forms or provide guidance on proper handling and incorporation into formulations are highly valued. This might include specific packaging solutions or recommendations for excipients.

In conclusion, all-trans-Retinol is a potent and versatile chemical compound with critical roles in human and animal health, as well as advanced cosmetic formulations. By engaging with reputable all-trans-Retinol manufacturers and understanding its chemical properties, businesses can effectively leverage this Vitamin A powerhouse to create market-leading products.