For chemists, procurement specialists, and safety officers, understanding the precise specifications and proper handling procedures for chemical compounds is fundamental. Alpha-Cyclopentylmandelic Acid (CAS 427-49-6) is a specialized organic compound used primarily as a pharmaceutical intermediate. This guide provides essential details regarding its characteristics, safety, and handling recommendations.

Chemical Identity and Specifications

Product Name: Alpha-Cyclopentylmandelic Acid
CAS Number: 427-49-6
Molecular Formula: C13H16O3
Molecular Weight: 220.26 g/mol
EINECS Number: 207-047-8
Synonyms: CM Acid, Cyclopentyl-hydroxy-phenyl-acetic acid, Cyclopentyl mandelic acid, Cyclopentylphenylglycolic acid.

Key Physical and Chemical Properties:

  • Appearance: White to pale brown solid.
  • Melting Point: Typically in the range of 144-150 °C. This range is a critical indicator of purity.
  • Boiling Point: Approximately 110 °C at 0.5 mmHg.
  • Assay/Purity: Commonly supplied with an assay of ≥98.0%. Higher purity is often available upon request for specialized applications.
  • Solubility: Slightly soluble in chloroform and methanol.

Safety Information and Handling Precautions

Alpha-Cyclopentylmandelic Acid is classified as an irritant. Proper safety protocols must be followed during handling and storage. Referencing the Material Safety Data Sheet (MSDS) provided by the manufacturer is crucial.

  • Hazard Codes: Typically C (Corrosive), Xi (Irritant).
  • Risk Statements: Common statements include R34 (Causes burns), R41 (Risk of serious damage to eyes), and R37/38 (Irritating to respiratory system and skin).
  • Safety Statements: Recommended precautions include S45 (In case of accident or if you feel unwell seek medical advice), S36/37/39 (Wear suitable protective clothing, gloves and eye/face protection), and S26 (In case of contact with eyes, rinse immediately with plenty of water and seek medical advice).
  • Personal Protective Equipment (PPE): Always wear appropriate chemical-resistant gloves, safety goggles or a face shield, and protective clothing. Ensure adequate ventilation or use a fume hood when handling.
  • Storage Conditions: Store in a cool, dry, and well-ventilated place. Keep the container tightly closed and protected from moisture and strong light/heat.

Applications and Procurement Guidance

Alpha-Cyclopentylmandelic Acid is primarily used as a pharmaceutical intermediate, particularly in the synthesis of muscarinic M3 receptor antagonists for respiratory ailments. It also serves as a reference standard for drug impurities. When purchasing this compound, it is advisable to buy from reputable manufacturers and suppliers in China who can provide detailed specifications and safety data.

Understanding these specifications and adhering to safety guidelines will ensure the effective and safe utilization of Alpha-Cyclopentylmandelic Acid in your laboratory or manufacturing processes. Always consult the most current MSDS for the most accurate and up-to-date safety information.