In the realm of natural product chemistry, Isoliquiritigenin (CAS 961-29-5) has emerged as a compound of significant interest due to its robust antioxidant and hepatoprotective properties. Derived from the roots of *Glycyrrhiza glabra*, this chalcone is increasingly recognized as a valuable ingredient for pharmaceutical research and the development of health-promoting agents. For procurement managers and scientists, understanding these benefits and securing a reliable supply from a reputable Isoliquiritigenin manufacturer is key.

Isoliquiritigenin's antioxidant capacity is attributed to its ability to scavenge reactive oxygen species (ROS) and modulate cellular defense mechanisms. It has been shown to protect cells against oxidative damage, particularly in contexts involving mitochondrial dysfunction. For instance, studies indicate that Isoliquiritigenin can protect cells from iron-catalyzed oxidative stress by activating AMP-activated protein kinase (AMPK), which in turn phosphorylates glycogen synthase kinase-3beta (GSK3beta). This pathway helps maintain cellular and mitochondrial integrity, highlighting its role in mitigating damage from ROS.

The hepatoprotective effects of Isoliquiritigenin are equally compelling. Research demonstrates its ability to protect the liver from injury induced by various toxins, such as carbon tetrachloride (CCl4). Isoliquiritigenin pretreatment has been shown to inhibit the reduction of cytochrome P450 2E1, an enzyme often implicated in toxic liver injury. Furthermore, it reverses the decrease in hepatic antioxidant capacity and suppresses the expression of pro-inflammatory markers like tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) in the liver. This makes it an attractive compound for developing therapeutic strategies against liver diseases.

For professionals looking to buy Isoliquiritigenin CAS 961-29-5, it is essential to source from suppliers who guarantee high purity and consistent quality. NINGBO INNO PHARMCHEM CO.,LTD., a leading Isoliquiritigenin supplier in China, provides research-grade Isoliquiritigenin that meets stringent quality standards. Our competitive Isoliquiritigenin price makes it accessible for a wide range of R&D projects, from early-stage research to formulation development.

By integrating Isoliquiritigenin into your research, you can explore its potential in combating oxidative stress-related diseases and liver conditions. We encourage you to contact us to discuss your procurement needs and discover the benefits of partnering with a reliable source for this important pharmaceutical intermediate.