Posted by NINGBO INNO PHARMCHEM CO.,LTD.

In the realm of pharmaceutical research and development, certain compounds emerge as indispensable tools for understanding complex biological processes. Antipyrine, also known as Phenazone (CAS 60-80-0), is one such compound. While historically recognized for its analgesic and antipyretic properties, its current significance is perhaps even greater in its role as a probe for studying drug metabolism and enzyme activity within the liver.

The liver is a central organ for drug metabolism, containing a variety of enzymes, most notably the cytochrome P450 (CYP) superfamily, that modify and break down foreign substances, including medications. Antipyrine is a well-established substrate for several of these CYP enzymes. This characteristic makes it an ideal compound for Antipyrine for drug metabolism studies. By measuring how quickly the body metabolizes Antipyrine, researchers can infer the activity levels of specific drug-metabolizing enzymes.

This method is crucial for several reasons. Firstly, it helps in assessing an individual's metabolic capacity, which can influence drug dosage and efficacy. Secondly, it allows scientists to investigate how other drugs, lifestyle factors, or diseases might affect enzyme activity. For instance, if a new drug is found to inhibit a certain CYP enzyme, it might also slow down the metabolism of Antipyrine, indicating a potential drug-drug interaction. This makes the phenylone intermediate supply invaluable for preclinical and clinical research.

The consistent availability of high-purity Antipyrine raw material purity is essential for these studies. Pharmaceutical companies and research institutions rely on suppliers that guarantee the quality and consistency of their pharmaceutical grade antipyrine. The detailed specifications and analytical data provided by a reputable phenylone intermediate manufacturer ensure that the results obtained from metabolism studies are accurate and reproducible.

In essence, Antipyrine (Phenazone) has transitioned from being a frontline medication to a critical research tool. Its predictable metabolic pathways and ability to serve as a surrogate marker for liver enzyme function solidify its place in modern pharmacological research, contributing to the safer and more effective development of new therapies.