API Intermediates: The Role of 2-Bromo-4-fluoro-5-nitrophenol

The pharmaceutical industry relies heavily on a consistent and high-quality supply of chemical intermediates for the synthesis of Active Pharmaceutical Ingredients (APIs). Among these crucial compounds is 2-Bromo-4-fluoro-5-nitrophenol (CAS 84478-87-5), a versatile building block that plays a significant role in the development of complex therapeutic agents. This article explores its significance as an API intermediate, its chemical properties, and why sourcing it from reliable API intermediates suppliers is essential for your R&D and manufacturing operations.

The Importance of 2-Bromo-4-fluoro-5-nitrophenol in API Synthesis

2-Bromo-4-fluoro-5-nitrophenol is a key precursor in the synthesis of molecules like isoindolinone and thienopyrimidine dione compounds. These heterocyclic structures are often found in molecules exhibiting potent biological activity, making this intermediate vital for drug discovery programs targeting various diseases. Its specific arrangement of bromine, fluorine, and nitro groups on a phenol ring provides reactive sites that chemists can leverage for targeted modifications and complex molecular assembly. When seeking to buy 2-Bromo-4-fluoro-5-nitrophenol, prioritizing purity is key to ensuring the efficacy and safety of the final API.

Chemical Properties and Handling Considerations

With a molecular formula of C6H3BrFNO3 and a molecular weight of approximately 236, 2-Bromo-4-fluoro-5-nitrophenol typically appears as a brown powder. Its chemical properties, such as melting point (124-127℃) and solubility, are critical for formulation and process development. Safety data, including hazard statements like H302 (Harmful if swallowed) and H315 (Causes skin irritation), must be thoroughly reviewed by laboratory personnel. Proper handling, including the use of personal protective equipment (PPE) and storage under inert gas, is essential when working with this compound. Understanding these properties is fundamental for R&D scientists and formulators.

Procuring 2-Bromo-4-fluoro-5-nitrophenol: Supplier Selection

The global market for API intermediates is competitive, and securing a dependable supplier for 2-Bromo-4-fluoro-5-nitrophenol is crucial. Companies specializing in fine chemicals and pharmaceutical intermediates are the primary sources. When evaluating potential vendors, consider their:

  • Purity Standards: Confirm that the product meets the required purity levels for pharmaceutical synthesis.
  • Regulatory Compliance: Look for suppliers who adhere to international standards like ISO 9001 and REACH.
  • Technical Support: A responsive supplier can offer valuable insights into product handling and application.
  • Pricing and Lead Times: Compare quotes and delivery schedules to ensure cost-effectiveness and timely project execution.

For businesses looking to purchase 2-Bromo-4-fluoro-5-nitrophenol, especially in bulk, sourcing from established manufacturers in regions like China often provides a balance of quality, cost, and supply chain stability. Understanding the CAS 84478-87-5 price range and negotiating terms with a reliable partner are key steps.