The pharmaceutical industry constantly seeks novel molecules to develop life-saving drugs. Central to this endeavor is the availability of high-quality chemical intermediates that can serve as the foundation for complex Active Pharmaceutical Ingredients (APIs). 1-Bromo-2-Fluoro-4-Iodobenzene (CAS 136434-77-0), also known by synonyms like 4-Bromo-3-fluoroiodobenzene, is one such indispensable building block, highly sought after by medicinal chemists and procurement specialists worldwide.

The Role of Halogenated Aromatics in Drug Development

Halogenated aromatic compounds, particularly those with multiple halogen substituents like 1-Bromo-2-Fluoro-4-Iodobenzene, are frequently employed in pharmaceutical synthesis. The halogens can:

  • Modulate Lipophilicity: Affecting how a drug is absorbed, distributed, metabolized, and excreted (ADME) properties.
  • Influence Receptor Binding: Contribute to specific interactions with biological targets through van der Waals forces or halogen bonding.
  • Serve as Reactive Handles: Enable the introduction of diverse functional groups via cross-coupling reactions or nucleophilic substitutions, facilitating the construction of complex drug scaffolds.

The strategic placement of bromine, fluorine, and iodine on the benzene ring of 1-Bromo-2-Fluoro-4-Iodobenzene provides medicinal chemists with exceptional control over synthesis. The iodine atom, for instance, is highly reactive in palladium-catalyzed cross-coupling reactions, while the fluorine atom can undergo nucleophilic aromatic substitution. This allows for sequential and selective functionalization, enabling the efficient synthesis of challenging molecular targets.

Applications in Pharmaceutical Synthesis

Researchers utilize 1-Bromo-2-Fluoro-4-Iodobenzene in the synthesis of various drug candidates and related molecules, including:

  • Factor Xa Inhibitors: Literature indicates its use in synthesizing potent and selective inhibitors, critical for anticoagulant therapies.
  • Carbazole Derivatives: Used as a precursor for carbazole-based compounds, a class known for diverse biological activities.
  • Other Complex Organic Molecules: It serves as a versatile intermediate for a wide array of therapeutic areas.

Where to Buy and Ensure Quality

For drug discovery programs, ensuring the quality and reliable supply of intermediates like 1-Bromo-2-Fluoro-4-Iodobenzene is paramount. Procurement managers should prioritize working with established manufacturers who can guarantee high purity levels (typically >97% or >99%) and provide comprehensive documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (CoA). When you need to buy 1-Bromo-2-Fluoro-4-Iodobenzene, consider these factors:

  • Supplier Reputation: Opt for suppliers with a proven track record in the pharmaceutical supply chain.
  • Quality Control Processes: Understand their analytical methods and quality assurance measures.
  • Scalability: Ensure the supplier can support your progression from early-stage research to later-stage development and commercialization.
  • Competitive Pricing: Obtaining cost-effective solutions is crucial in pharmaceutical R&D budgets.

NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier and manufacturer of 1-Bromo-2-Fluoro-4-Iodobenzene, offering high-purity materials and reliable service to the pharmaceutical industry. We encourage you to contact us to discuss how we can support your drug discovery initiatives.