The endocannabinoid system (ECS) is a complex network that scientists are increasingly investigating for its therapeutic potential. Central to this system is 2-Arachidonoylglycerol (2-AG), a lipid mediator that acts as a full agonist for cannabinoid receptors. For pharmacologists and researchers, understanding and utilizing 2-AG is key to unlocking new avenues in drug discovery and understanding biological mechanisms.

2-AG: A Key Player in Receptor Pharmacology

2-Arachidonoylglycerol (CAS 53847-30-6) is an endogenous compound that effectively binds to and activates both CB1 and CB2 receptors. Its role as a full agonist means it can elicit a maximum response from these receptors, making it an invaluable tool for studying receptor-ligand interactions. Pharmacological research often employs 2-AG to investigate the downstream signaling pathways mediated by cannabinoid receptors. This includes exploring its effects on neurotransmitter release, cellular excitability, and immune cell function.

Diverse Applications in Pharmacological Research

The research applications for 2-AG are extensive and growing:

  • Neuroscience: Investigating the role of the ECS in conditions like anxiety, depression, pain, and neurodegenerative diseases. 2-AG's ability to modulate neural activity makes it a focal point for understanding brain function.
  • Pain Management: Studying how cannabinoid receptor activation influences pain perception and developing non-addictive analgesics.
  • Inflammation and Immunity: Exploring the immunomodulatory effects of 2-AG and its potential in treating inflammatory disorders.
  • Metabolic Research: Understanding the ECS's involvement in appetite regulation, energy homeostasis, and metabolic syndrome.
  • Drug Discovery: Using 2-AG as a reference compound or starting point for designing novel synthetic cannabinoids or ECS modulators.

When researchers decide to buy 2-AG, they are acquiring a fundamental tool to probe these complex biological systems. The availability of high-purity 2-AG from reliable manufacturers and suppliers is crucial for the accuracy and reproducibility of these studies.

Sourcing High-Quality 2-AG

Procuring 2-Arachidonoylglycerol requires careful consideration of the supplier. Reputable manufacturers and suppliers ensure that the compound meets stringent purity standards (e.g., ≥95%), providing detailed Certificates of Analysis. This guarantees that researchers are working with the intended molecule and can trust their experimental results. Many institutions source their 2-AG from specialized chemical suppliers, often in China, which are known for their expertise in synthesizing and distributing fine chemicals and pharmaceutical intermediates. The price for 2-AG will depend on purity, quantity, and the supplier's reputation, but investing in quality is essential for scientific integrity.

In essence, 2-Arachidonoylglycerol is a cornerstone compound for modern pharmacological research. Its potent agonist activity and widespread presence within the ECS make it an indispensable resource for advancing our understanding of health and disease. By partnering with trusted sources, researchers can confidently access the high-purity 2-AG needed to drive innovation.