In the realm of pharmaceutical research and development, the selection of precise chemical intermediates is critical. 1-Bromo-5-Fluoropentane (CAS 407-97-6) has emerged as a compound of significant interest due to its versatile applications, particularly in the synthesis of advanced pharmaceutical agents. Understanding its utility can help researchers and procurement managers identify its value for their specific needs.

Key Role in Medical Imaging Agents

One of the most prominent applications of 1-Bromo-5-Fluoropentane is its use as a precursor in the synthesis of 18F-labeled compounds. Specifically, it is employed in the preparation of (anilido)piperidine derivatives that serve as μ-opioid receptor imaging agents. These agents are invaluable tools in Positron Emission Tomography (PET) scans, allowing for detailed visualization and study of opioid receptor distribution and density in the brain. For institutions involved in neuroimaging research or the development of diagnostic tools, sourcing high-purity 1-Bromo-5-Fluoropentane from a reliable manufacturer is essential to ensure the accuracy and efficacy of the final imaging agents.

Versatility in Organic Synthesis

Beyond its role in imaging agents, 1-Bromo-5-Fluoropentane is a valuable building block in broader organic synthesis. Its structure, containing both a reactive bromine atom and a fluorine atom, allows for a range of chemical transformations. It can be utilized in nucleophilic substitution reactions, Grignard reagent formation, and other coupling reactions to introduce fluorinated alkyl chains into larger, more complex molecules. This versatility makes it attractive for chemists synthesizing novel drug candidates with improved pharmacological properties, such as enhanced metabolic stability or increased lipophilicity, which can positively influence absorption, distribution, metabolism, and excretion (ADME) profiles. Researchers looking to buy this compound for drug discovery efforts will find its chemical reactivity to be a significant asset.

Specialty Solvent and Chemical Reagent

In certain niche applications, 1-Bromo-5-Fluoropentane can also function as a selective solvent. Its ability to dissolve specific substances, such as in the purification of pyruvic acid, highlights its diverse chemical utility. As a specialty chemical reagent, its availability from a trusted supplier ensures that experimental protocols can be executed with precision and reproducibility.

Procurement Considerations

When procuring 1-Bromo-5-Fluoropentane, researchers should prioritize suppliers who offer stringent quality control, typically ensuring a purity of ≥99%. Companies seeking to purchase this intermediate should seek out experienced manufacturers who can provide detailed technical data, including CAS number (407-97-6), molecular formula (C5H10BrF), and safety information. Engaging with suppliers who offer competitive prices and reliable delivery from regions like China can further enhance the efficiency of research projects. Requesting a quote from established chemical providers is a standard practice to ensure the best value and quality.

In conclusion, 1-Bromo-5-Fluoropentane is a key chemical intermediate with significant impact in pharmaceutical research, particularly in the development of diagnostic imaging agents and the synthesis of novel therapeutic molecules. Its availability from reputable global suppliers makes it an accessible and valuable resource for the scientific community.