Applications of 4-Iodo-1-methyl-1H-pyrazole in Pharmaceutical Synthesis
The pharmaceutical industry constantly seeks novel molecular entities with improved efficacy and safety profiles. This pursuit relies heavily on the availability of versatile chemical building blocks that can be efficiently transformed into complex drug candidates. 4-Iodo-1-methyl-1H-pyrazole (CAS 39806-90-1) has emerged as a valuable intermediate in this context, offering a unique pyrazole scaffold with a reactive iodine atom that facilitates diverse synthetic pathways.
The reactivity of the iodo group in 4-Iodo-1-methyl-1H-pyrazole makes it an ideal substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki, Stille, and Buchwald-Hartwig aminations. These reactions are fundamental in drug discovery for constructing diverse libraries of compounds, enabling medicinal chemists to explore structure-activity relationships (SAR) efficiently. By incorporating different aryl, vinyl, or alkyl groups, or introducing amine functionalities, researchers can systematically modify molecular structures to optimize biological activity.
The pyrazole moiety itself is a privileged structure in medicinal chemistry, found in numerous marketed drugs with a wide range of therapeutic applications, including anti-inflammatory agents, kinase inhibitors, and antiviral compounds. The methyl substituent on the nitrogen atom of 4-Iodo-1-methyl-1H-pyrazole offers a stable point of attachment, preventing unwanted rearrangements or functionalization at that position. This specificity is crucial when aiming to synthesize a precise target molecule.
For pharmaceutical companies and contract research organizations (CROs), sourcing reliable quantities of high-purity 4-Iodo-1-methyl-1H-pyrazole from established manufacturers is paramount. When you need to buy this critical intermediate, engaging with a supplier that demonstrates consistent quality and a robust supply chain ensures uninterrupted research and development. Understanding the price and availability from reputable chemical suppliers, especially those in China, can greatly facilitate the drug discovery process.
Perspectives & Insights
Molecule Vision 7
“By incorporating different aryl, vinyl, or alkyl groups, or introducing amine functionalities, researchers can systematically modify molecular structures to optimize biological activity.”
Alpha Origin 24
“The pyrazole moiety itself is a privileged structure in medicinal chemistry, found in numerous marketed drugs with a wide range of therapeutic applications, including anti-inflammatory agents, kinase inhibitors, and antiviral compounds.”
Future Analyst X
“The methyl substituent on the nitrogen atom of 4-Iodo-1-methyl-1H-pyrazole offers a stable point of attachment, preventing unwanted rearrangements or functionalization at that position.”