2-Hydroxyterephthalic Acid (CAS: 636-94-2), often abbreviated as HTA, is a versatile organic compound that has garnered significant attention across various scientific and industrial domains. Its unique chemical structure, featuring both carboxylic acid groups and a hydroxyl substituent on a benzene ring, makes it a valuable intermediate in pharmaceutical synthesis and a key building block for advanced materials like Metal-Organic Frameworks (MOFs) and Covalent Organic Frameworks (COFs).

The synthesis of high-purity 2-Hydroxyterephthalic Acid is a critical factor for its successful application. Leading chemical manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD., employ optimized synthesis routes. One common and efficient method involves a modified Koble-Schmitt atmospheric carboxylation process. This technique, often utilizing conditions like heating at 230-240°C in the presence of potassium carbonate and potassium formate, allows for the preparation of crude HTA. Subsequent purification through acid-alkali refining yields polymerization-grade HTA with exceptional purity, often exceeding 99.5%, and minimal metal ion contamination. This refined product is vital for demanding applications.

The utility of 2-Hydroxyterephthalic Acid spans several key areas:

  • Pharmaceutical Intermediates: HTA serves as a crucial starting material or intermediate in the synthesis of various APIs. Its structure can be modified to create complex drug molecules with specific therapeutic properties. For pharmaceutical companies, sourcing high-purity HTA from reliable manufacturers ensures the quality and efficacy of their final drug products.
  • MOF and COF Synthesis: As a dicarboxylate linker, HTA is instrumental in the construction of porous crystalline materials known as MOFs and COFs. The hydroxyl group present on the linker can influence the framework's properties, such as its affinity for certain gases or its catalytic activity. These materials are actively researched for applications in gas storage, separation technologies, and catalysis.
  • Material Science and Polymer Modification: The unique functional groups in HTA also make it suitable for modifying high-performance polymers. It can be incorporated as a monomer to enhance properties like thermal stability, mechanical strength, and flame retardancy in various polymeric materials.

When procurement professionals and research scientists look to buy 2-Hydroxyterephthalic Acid, partnering with a reputable manufacturer in China like NINGBO INNO PHARMCHEM CO.,LTD. is advantageous. They offer competitive pricing, consistent quality, and a broad spectrum of services, including customized synthesis and reliable logistics. Ensuring access to high-purity HTA through a dependable supplier empowers innovation in both the pharmaceutical industry and the rapidly evolving field of material science.

In summary, the efficient synthesis and strategic application of 2-Hydroxyterephthalic Acid underscore its importance as a chemical intermediate. By understanding its properties and sourcing it from qualified manufacturers, researchers and industries can unlock its full potential.