Verteporfin, a compound identified by CAS number 129497-78-5, has emerged as a molecule of significant interest across multiple research disciplines, primarily due to its dual capabilities: acting as a potent YAP inhibitor and serving as an effective photosensitizer for photodynamic therapy (PDT). As researchers increasingly look to purchase this versatile chemical, understanding its broad range of applications is crucial for guiding experimental design and therapeutic development. Sourced from reputable manufacturers, often in China, Verteporfin (appearing as a dark green to black solid) is a key component in cutting-edge scientific investigations.

One of the most significant research applications of Verteporfin is in the study of the Hippo signaling pathway. This pathway is a fundamental regulator of cell growth, proliferation, and tissue homeostasis. YAP (Yes-associated Protein), a key downstream effector of this pathway, has been implicated in the development and progression of numerous cancers. Verteporfin functions by disrupting the interaction between YAP and its transcriptional partners, the TEAD family of transcription factors. This inhibition can suppress tumor cell growth, stem cell properties, and resistance to chemotherapy. Laboratories investigating novel oncology treatments frequently seek to buy Verteporfin to probe these mechanisms and explore its potential as an anti-cancer agent. The availability from reliable suppliers ensures that researchers can access this vital tool for their studies.

Beyond its role in cancer research, Verteporfin is well-established as a photosensitizer for photodynamic therapy. PDT is a treatment modality that uses a photosensitive drug and light to kill abnormal cells, particularly those involved in cancerous growth or abnormal neovascularization. Verteporfin accumulates in target cells, and upon illumination with specific wavelengths of light, it generates reactive oxygen species (ROS) that induce localized cell death. This application has found significant utility in ophthalmology, for instance, in treating wet age-related macular degeneration by eliminating aberrant blood vessels in the eye. Pharmaceutical companies developing PDT agents often need to purchase Verteporfin from qualified manufacturers to incorporate into their drug formulations.

Furthermore, Verteporfin's impact extends to stem cell biology and developmental research. Its ability to modulate YAP signaling can influence cell fate decisions and differentiation processes. Researchers are exploring its use in generating or controlling specific cell types, which has implications for regenerative medicine and developmental biology studies. The precise control over cellular processes offered by Verteporfin makes it an attractive compound for scientists aiming to understand complex biological phenomena at a cellular level.

The consistent demand for Verteporfin necessitates a reliable supply chain. Companies looking to buy Verteporfin for their research initiatives should seek out suppliers who can guarantee purity, provide comprehensive documentation, and offer competitive pricing. Whether for fundamental research into signaling pathways, the development of next-generation cancer therapies, or advanced ophthalmological treatments, Verteporfin (CAS 129497-78-5) remains a cornerstone compound in modern scientific exploration. Engaging with established manufacturers ensures access to this critical research chemical.