The pharmaceutical industry constantly seeks advanced chemical building blocks to facilitate the development of new and improved therapeutics. Within the field of peptide-based drug discovery, precisely protected amino acids are indispensable. N2-Boc-N6-acetyl-L-lysine, commonly known as Boc-Lys(Ac)-OH (CAS: 6404-26-8), is one such critical compound, offering unique advantages for pharmaceutical researchers and manufacturers. As a leading supplier and manufacturer, we are committed to providing the high-purity materials that drive progress in this vital sector.

Understanding the Chemical Significance of Boc-Lys(Ac)-OH

Boc-Lys(Ac)-OH is a derivative of lysine, an amino acid with a versatile side chain containing a primary amino group. In this derivative, the alpha-amino group is protected by the acid-labile tert-butyloxycarbonyl (Boc) group, while the epsilon-amino group on the side chain is protected by an acetyl (Ac) group. This dual protection strategy is invaluable in peptide synthesis, especially when it's necessary to incorporate lysine residues and then selectively deprotect either the alpha-amino group or the side-chain amino group at different stages of synthesis. The chemical formula for Boc-Lys(Ac)-OH is C13H24N2O5, and it has a molecular weight of 288.34 g/mol. It is typically supplied as a white powder.

Critical Role in Pharmaceutical Research and Development

The pharmaceutical applications of Boc-Lys(Ac)-OH are primarily centered around its use in the synthesis of peptides with therapeutic potential. Peptides are increasingly being developed as drugs due to their specificity and efficacy, but their synthesis requires careful management of reactive functional groups. Boc-Lys(Ac)-OH allows for:

  • Controlled Peptide Assembly: Enabling the sequential addition of amino acids in SPPS without unwanted side reactions at the lysine side chain.
  • Creation of Modified Peptides: Facilitating the attachment of drugs, imaging agents, or targeting moieties to the lysine side chain after selective deprotection.
  • Synthesis of Peptidomimetics: Providing a versatile scaffold for creating non-peptide molecules that mimic peptide structures.

The acetyl group on the epsilon-amino function offers a different deprotection condition compared to the Boc group, allowing for orthogonal strategies essential in complex synthetic schemes common in API manufacturing.

Why Partner with a Trusted Manufacturer and Supplier?

For pharmaceutical research and manufacturing, sourcing chemicals requires an unwavering commitment to quality, consistency, and reliable supply. As a dedicated manufacturer and supplier of fine chemical intermediates from China, we understand these demands. When you purchase Boc-Lys(Ac)-OH from us, you are assured of a product that meets high purity standards, crucial for ensuring the success and reproducibility of your pharmaceutical synthesis. We provide comprehensive documentation and support, ensuring that our materials contribute positively to your drug development pipeline. Our focus on competitive pricing and dependable delivery makes us an ideal partner for both research labs and larger-scale production facilities.

Investing in high-quality Boc-Lys(Ac)-OH from a trusted source like ours is a strategic decision that supports efficient drug discovery and development. We are here to provide the essential chemical tools you need to bring innovative pharmaceutical solutions to market.