The efficiency and success of synthesizing complex organic molecules, particularly in the pharmaceutical industry, hinge on the availability of high-quality chemical intermediates. Benzyl 3-oxo-1-piperidinecarboxylate, CAS number 61995-20-8, is a prime example of such a compound, serving as a critical building block in various synthetic routes. Understanding its properties, synthesis, and procurement channels is essential for any R&D chemist or procurement manager.

Chemical Properties and Significance of Benzyl 3-oxo-1-piperidinecarboxylate

Benzyl 3-oxo-1-piperidinecarboxylate, also referred to as 1-Cbz-3-piperidinone, is characterized by its molecular formula C₁₃H₁₅NO₃. It is typically supplied as a light yellow liquid, with a standard purity of 97% or higher. The compound integrates a piperidine ring system with a ketone at the 3-position and a benzyloxycarbonyl (Cbz) protecting group on the nitrogen atom. This structural arrangement makes it highly useful in organic synthesis:

  • Versatile Reactivity: The ketone group allows for a range of reactions, including nucleophilic addition and reduction, while the Cbz group provides stable protection for the amine, removable under specific conditions.
  • Pharmaceutical Applications: It acts as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs), including potential anticancer agents, enzyme inhibitors, and compounds used in treating neurological disorders.
  • Peptide Synthesis: Its structure can be adapted for use in creating modified amino acids or peptide mimetics, enhancing the properties of peptide-based therapeutics.

Researchers aiming to buy Benzyl 3-oxo-1-piperidinecarboxylate are often driven by the need for a reliable building block that can facilitate the construction of complex molecular architectures.

Synthesis Pathways and Sourcing Considerations

The synthesis of Benzyl 3-oxo-1-piperidinecarboxylate typically involves reacting 3-piperidone with benzyl chloroformate in the presence of a base. This method ensures a relatively high yield and purity, making it suitable for commercial production.

For procurement, particularly in the global market, China has become a predominant source for such chemical intermediates. When you need to purchase Benzyl 3-oxo-1-piperidinecarboxylate, working with a reputable manufacturer or supplier from China offers distinct advantages:

  • Cost-Effectiveness: Competitive pricing structures enable R&D departments to manage budgets effectively.
  • Quality Control: Established Chinese chemical companies adhere to stringent quality standards, providing products with guaranteed purity (e.g., 97% min) and detailed Certificates of Analysis (CoA).
  • Scalability: These suppliers are equipped to handle orders ranging from gram quantities for initial research to multi-kilogram batches for pilot or commercial production.

When searching for suppliers of CAS 61995-20-8, it’s important to prioritize those with a strong commitment to product quality and customer service. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to meeting these demands.

In summary, Benzyl 3-oxo-1-piperidinecarboxylate is an indispensable intermediate for many synthetic chemists. By strategically sourcing this compound from reliable Chinese manufacturers, researchers can ensure access to high-quality materials at favorable prices, thereby advancing their critical projects in drug discovery and development.