The pharmaceutical industry relies heavily on high-quality chemical intermediates to synthesize complex Active Pharmaceutical Ingredients (APIs) and advanced drug molecules. Among these vital compounds is Benzyl methyl malonate (CAS 52267-39-7), a versatile ester that plays a significant role in various synthetic pathways. For research scientists and product formulators, understanding its properties and sourcing it effectively is key to successful drug development.

The Chemical Profile of Benzyl Methyl Malonate

Benzyl methyl malonate, with its molecular formula C11H12O4 and molecular weight of 208.21 g/mol, is characterized by its ester functionalities and a benzyl group. This structure lends itself to a range of chemical reactions, making it an adaptable building block. While chemicalbook.com and other resources list its properties, including a boiling point of 333.5 °C at 760 mmHg and a flash point of 129.5 °C, its primary value lies in its reactivity in synthesis.

Applications in Pharmaceutical Synthesis

The utility of Benzyl methyl malonate in pharmaceutical synthesis stems from its ability to participate in reactions that build complex organic skeletons. It is frequently used:

  • As a reactant in the synthesis of alkaloids, contributing to the construction of intricate pentacyclic structures.
  • In the preparation of specific mercapto-containing compounds, which have shown efficacy as inhibitors in biological pathways, such as those related to thrombin activatable fibrinolysis inhibitor.
  • As a chiral building block or a precursor to chiral synthons, enabling the stereoselective synthesis of drug candidates.

Researchers leverage Benzyl methyl malonate to introduce the malonate moiety with a protected benzyl group, allowing for selective deprotection and further functionalization. This makes it a valuable tool for chemists engaged in medicinal chemistry and process development.

Sourcing High-Purity Benzyl Methyl Malonate

For pharmaceutical applications, the purity of Benzyl methyl malonate is non-negotiable. Suppliers typically offer grades with purity levels of 96% or higher, often verified by GC. When looking to buy Benzyl methyl malonate, it is essential to partner with reliable manufacturers and suppliers. Many pharmaceutical companies source this intermediate from Chinese chemical manufacturers who can provide high-purity material at competitive prices. Obtaining a quotation from a trusted supplier ensures that you receive a product that meets rigorous industry standards and supports efficient drug synthesis.

Choosing the Right Supplier

When selecting a supplier for Benzyl methyl malonate (CAS 52267-39-7), consider factors such as:

  • Quality Control: Ensure they provide detailed CoAs and adhere to strict quality management systems.
  • Production Capacity: Verify their ability to meet your volume requirements consistently.
  • Technical Support: A supplier offering technical assistance can be invaluable for optimizing your synthesis processes.
  • Regulatory Compliance: Confirm they meet international standards and can provide necessary documentation.

By focusing on these aspects, research scientists and procurement teams can secure a stable supply of Benzyl methyl malonate, facilitating the efficient development and production of life-saving pharmaceuticals.