In the realm of biochemical research, the quality and purity of reagents directly influence the accuracy and reproducibility of experimental outcomes. L-Histidine (CAS 71-00-1) is a fundamental amino acid that serves as a vital biochemical reagent, playing critical roles in enzyme kinetics, protein structure studies, and metabolic pathway investigations. For researchers and procurement specialists in laboratories and research institutions, understanding the specifications and sourcing reliable L-Histidine is essential.

L-Histidine's unique imidazole side chain is central to its function in biological systems. It acts as a proton donor or acceptor in enzyme active sites, participates in metal ion coordination critical for metalloenzymes, and contributes to the overall charge and conformation of proteins. As a biochemical reagent, it is used in cell culture media, as a component in buffer solutions, and in various analytical assays. The purity of L-Histidine is of utmost importance; even trace impurities can affect enzymatic activity or interfere with sensitive analytical techniques. Therefore, researchers should look for L-Histidine with high purity levels, typically exceeding 99%, and with well-documented specifications and lot-specific Certificates of Analysis (CoA).

When looking to purchase L-Histidine for research purposes, selecting a reputable supplier is key. Many leading chemical suppliers, including those based in China, offer L-Histidine suitable for biochemical applications. These suppliers often adhere to quality management systems, such as ISO 9001, and provide detailed product information. It is advisable to compare specifications from different manufacturers and suppliers, considering factors like appearance, specific rotation, and limits for impurities like heavy metals and residue on ignition.

For researchers requiring bulk quantities or specific grades of L-Histidine, engaging with manufacturers directly can be beneficial. This allows for potentially better pricing and the opportunity to discuss custom packaging or specific analytical requirements. The goal is to establish a relationship with a supplier who can consistently provide high-quality L-Histidine, ensuring the integrity of your research. By prioritizing quality and reliability, scientists can confidently utilize L-Histidine as a biochemical reagent, advancing their studies in molecular biology, biochemistry, and related fields.