In the realm of pharmaceutical research, understanding drug metabolism is crucial for effective drug development and therapy. Bis(4-cyanophenyl)methanol (CAS 134521-16-7) plays a significant role in this field, particularly as a known metabolite of Letrozole. This article delves into the chemical nature of Bis(4-cyanophenyl)methanol and its importance for researchers and formulators.

The Chemical Profile of Bis(4-cyanophenyl)methanol

Bis(4-cyanophenyl)methanol is characterized by its chemical formula C15H10N2O and a molecular weight of 234.25. Typically appearing as an off-white powder, this compound's structure is central to its function as a metabolite. The identification and synthesis of such metabolites are vital for comprehensive drug analysis and study.

Significance as a Letrozole Metabolite

Letrozole is a potent aromatase inhibitor used in the treatment of hormone-receptor-positive breast cancer. During drug metabolism studies, it is essential to identify and quantify the various metabolites formed in the body. Bis(4-cyanophenyl)methanol has been identified as one such metabolite, meaning it is a product of the body's processing of Letrozole. Understanding these metabolic pathways provides insights into a drug's efficacy, duration of action, and potential side effects.

Applications in Pharmaceutical Research and Development

For pharmaceutical companies and research institutions, having access to high-purity Bis(4-cyanophenyl)methanol is critical for several reasons:

  • Analytical Standards: It serves as a reference standard for detecting and quantifying Letrozole metabolites in biological samples, crucial for pharmacokinetic studies and therapeutic drug monitoring.
  • Drug Discovery: Knowledge of metabolites can guide the design of new drugs with improved properties, such as longer half-lives or reduced toxicity.
  • Quality Control: Ensuring the purity of pharmaceutical products requires the identification and control of any potential impurities or related substances, including metabolites.

Sourcing High-Quality Bis(4-cyanophenyl)methanol

As a trusted manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. offers Bis(4-cyanophenyl)methanol with a guaranteed purity of ≥96% (HPLC). We understand the stringent requirements of pharmaceutical research and are dedicated to providing reliable chemical intermediates. If your work involves Letrozole or related endocrine therapies, procuring this metabolite from a reputable source like ours is essential for accurate and reproducible results. Contact us to obtain a quote and ensure your research is supported by quality materials.