In the intricate landscape of modern chemical synthesis, particularly within the pharmaceutical and biotechnology sectors, specialized building blocks are indispensable for innovation. Boc-D-2-Cyanophenylalanine, known by its CAS number 261380-28-3 and often referred to as Boc-D-2-CN-phe, is one such compound. Its unique structure, featuring the Boc protecting group and a cyano-substituted phenyl ring, makes it a valuable intermediate for a variety of research and development applications, most notably in peptide synthesis.

Synthesis and Quality Assurance of Boc-D-2-CN-phe

The synthesis of Boc-D-2-Cyanophenylalanine typically involves a series of controlled chemical reactions to introduce the Boc protection onto the amine group of D-2-Cyanophenylalanine, ensuring the desired stereochemistry is maintained. For its use in demanding applications like peptide synthesis and drug discovery, high purity is paramount. Reputable manufacturers often guarantee purity levels exceeding 97%, confirmed through rigorous analytical techniques such as High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy. Maintaining strict quality control throughout the production process is essential to provide researchers with reliable and consistent materials, ensuring reproducible experimental outcomes.

Applications Driving Demand

The demand for Boc-D-2-CN-phe is driven by its significant utility in several key areas:

  • Peptide Synthesis: As a protected, unnatural amino acid, it allows for the incorporation of specific structural modifications into peptides, which can enhance their therapeutic properties, stability, or target binding.
  • Medicinal Chemistry: It serves as a versatile intermediate in the synthesis of novel small molecules for drug discovery programs. The cyano group can influence pharmacokinetic properties or interact with biological targets.
  • Biochemical Research: It is used in studies to understand protein-ligand interactions, enzyme mechanisms, and to develop new diagnostic tools or probes.

Navigating the Purchasing Process

For procurement managers and research scientists needing to buy Boc-D-2-Cyanophenylalanine, selecting a trustworthy supplier is key. Key considerations include:

  • Supplier Reputation: Choose manufacturers and suppliers with a strong history of delivering high-quality fine chemicals and intermediates. Many opt for established suppliers known for their commitment to quality and customer service.
  • Product Specifications: Always verify that the product meets your required purity levels (e.g., ≥97% HPLC) and that a comprehensive Certificate of Analysis (CoA) is provided.
  • Pricing and Bulk Orders: Obtain quotes for the quantities needed. Suppliers often offer tiered pricing for bulk purchases, making it cost-effective for larger research projects or pilot-scale production.
  • Availability and Lead Times: Confirm the availability of the product and understand the estimated delivery times to ensure project continuity.

By focusing on these aspects, researchers can confidently source Boc-D-2-Cyanophenylalanine from reliable manufacturers and suppliers, ensuring the success of their critical R&D efforts.