In the realm of organic chemistry and pharmaceutical development, precise intermediates are the linchpins of innovation. Boc-D-Proline, also identified by its CAS number 37784-17-1, is one such critical compound. As a protected derivative of the amino acid D-proline, it offers chemists a reliable tool for constructing complex molecular architectures. Its unique properties make it highly sought after in sectors ranging from drug discovery to advanced materials science.

Key Characteristics and Importance of Boc-D-Proline

Boc-D-Proline is chemically known as N-(tert-Butoxycarbonyl)-D-proline. The tert-butoxycarbonyl (Boc) group is a widely used protecting group for amines, offering stability during various synthetic steps while allowing for facile removal under mild acidic conditions. This feature is particularly valuable in multi-step organic syntheses, preventing unwanted side reactions and enabling controlled functionalization.

The D-configuration of proline is also significant. Unlike the L-amino acids that are predominant in biological systems, D-amino acids can confer unique properties to peptides and small molecules, such as enhanced resistance to enzymatic degradation and altered conformational preferences. This makes Boc-D-Proline an essential component for:

  • Pharmaceutical Synthesis: It serves as a key intermediate in the production of various APIs. Its applications include the synthesis of inhibitors for enzymes like histone deacetylases (HDACs) and caspases, which are targets in cancer therapy and other medical fields. The chiral purity of Boc-D-Proline ensures the stereospecificity of the final drug product.
  • Peptide Chemistry: In the development of peptide-based drugs and research peptides, Boc-D-Proline is used to incorporate D-proline residues, which can improve peptide stability, binding affinity, and overall therapeutic profile.
  • Fine Chemical Manufacturing: Its well-defined chemical properties and reactivity make it a versatile building block for a wide array of specialized chemical products.

Procurement and Supplier Information

When seeking to buy Boc-D-Proline, buyers prioritize product quality, consistent availability, and competitive pricing. Key specifications to confirm include:

  • Purity: High purity, typically u226598%, is essential for reliable synthetic outcomes.
  • CAS Number: The correct identifier is 37784-17-1.
  • Appearance: It is usually supplied as a white crystalline powder.
  • Stability: Low loss on drying (u22640.5%) is indicative of good quality.

Many reputable chemical manufacturers, particularly those based in China, offer Boc-D-Proline. These suppliers often provide comprehensive Certificates of Analysis (CoA) to verify product specifications and batch consistency. For bulk purchases required for industrial manufacturing, these suppliers can offer cost advantages and ensure a stable supply chain. Researchers can also access smaller quantities for laboratory use.

In conclusion, Boc-D-Proline is a fundamental intermediate that empowers progress in the chemical and pharmaceutical sectors. Its specialized chemical nature and diverse applications underscore its critical importance in modern scientific endeavors.