The field of peptide chemistry is continuously pushing boundaries, driven by the development of new therapeutic agents, diagnostics, and biomaterials. Central to this progress is the availability of sophisticated amino acid building blocks that confer unique properties upon the resulting peptides. Boc-L-3,5-difluorophenylalanine (CAS: 205445-52-9) stands out as a particularly valuable intermediate, offering a gateway to enhanced peptide performance through strategic fluorination.

The Significance of Fluorinated Phenylalanine Derivatives

Phenylalanine, an aromatic amino acid, plays a crucial role in protein structure and function. Modifying its structure, especially through fluorination, can unlock a host of advantageous properties. The introduction of fluorine atoms onto the phenyl ring of phenylalanine, as seen in Boc-L-3,5-difluorophenylalanine, impacts molecular properties in several key ways:

  • Altered Electronic Distribution: Fluorine's high electronegativity withdraws electron density from the phenyl ring, influencing pi-stacking interactions and hydrogen bonding capabilities. This can refine peptide-target interactions.
  • Increased Lipophilicity: Fluorine atoms can enhance the lipophilicity of peptides, promoting better penetration through biological membranes, which is critical for oral bioavailability and intracellular delivery.
  • Metabolic Resistance: The strong C-F bond is resistant to metabolic cleavage, thereby increasing the in vivo stability of peptides containing this modified amino acid. This translates to longer duration of action and potentially reduced dosing frequency.

Boc-L-3,5-difluorophenylalanine in Peptide Synthesis

The Boc (tert-butyloxycarbonyl) protecting group on the alpha-amino function is standard for many peptide synthesis methodologies, particularly Fmoc/tBu solid-phase peptide synthesis (SPPS). This protection allows for selective coupling of the amino acid to a growing peptide chain, preventing unwanted side reactions. As a leading manufacturer and supplier, we provide Boc-L-3,5-difluorophenylalanine that is meticulously synthesized and purified to ensure high quality for demanding peptide synthesis applications.

Novel Applications and Research Avenues

Researchers are actively exploring the utility of Boc-L-3,5-difluorophenylalanine in a variety of cutting-edge applications:

  • Therapeutic Peptides: Development of peptide drugs for oncology, metabolic diseases, and neurological disorders benefits from the improved stability and bioavailability conferred by this fluorinated building block. Many scientists look to buy this compound to enhance their peptide drug candidates.
  • Peptidomimetics: It can be incorporated into non-peptide molecules that mimic the biological activity of peptides, offering greater stability and ease of administration.
  • Biomaterials and Drug Delivery Systems: The unique properties of fluorinated peptides may also find application in advanced drug delivery systems and biocompatible materials.

Where to Buy Boc-L-3,5-difluorophenylalanine

For researchers and developers seeking to leverage the advantages of Boc-L-3,5-difluorophenylalanine, sourcing from a reputable supplier is key. We offer this critical intermediate with guaranteed high purity and competitive pricing. Our commitment as a manufacturer ensures a reliable supply chain, supporting your project from initial research to larger-scale production. We understand the importance of timely access to high-quality materials for successful drug development.

To learn more about the specifications and applications of Boc-L-3,5-difluorophenylalanine, or to request a quote, please contact us. Empower your peptide chemistry research with our premium intermediates.