For professionals in the chemical and pharmaceutical industries, a deep understanding of key intermediates is vital for successful research and manufacturing. Boc-L-Leucine Monohydrate (CAS 13139-15-6) is a prominent example, valued for its specific chemical properties and its extensive use as a building block in synthesis. This article delves into the characteristics of this compound and its critical applications, highlighting why sourcing it from reputable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is advantageous.

Chemical Identity and Properties: Boc-L-Leucine Monohydrate, with the molecular formula C11H21NO4·H2O, is a derivative of the amino acid L-leucine. The 'Boc' prefix refers to the tert-butyloxycarbonyl group attached to the alpha-amino nitrogen. This protecting group renders the amino nitrogen less nucleophilic and basic, allowing for selective reactions at other functional groups within a molecule or in controlled step-wise synthesis. Its physical appearance is typically a white crystalline powder. The monohydrate form indicates the presence of one molecule of water per molecule of Boc-L-leucine, a common and stable crystalline form. Key properties, such as its melting point, solubility, and optical rotation, are important for chemists to consider during reaction design and process optimization. Sourcing from a manufacturer that provides precise specifications for these properties ensures predictability in application.

Role in Peptide Synthesis: The primary application for Boc-L-Leucine Monohydrate is within peptide synthesis. In this field, it functions as a protected amino acid residue that can be coupled sequentially to other amino acids or peptide fragments. The Boc group offers stability under a range of reaction conditions and can be reliably cleaved using acidic reagents (e.g., trifluoroacetic acid, TFA), revealing the free amine for subsequent coupling. This controlled deprotection and coupling strategy is the backbone of solid-phase peptide synthesis (SPPS), a technique crucial for generating peptides for research, diagnostics, and therapeutics. Procurement managers looking to buy this for their synthesis campaigns will value suppliers offering high-purity material to ensure the integrity of the peptide chain.

Biochemical Research and Other Applications: Beyond its direct role in peptide chain assembly, Boc-L-Leucine Monohydrate can also serve as a substrate in biochemical studies, such as investigating enzyme kinetics or protein-ligand interactions. Its structure makes it amenable to modification or incorporation into more complex biomolecules. Researchers may purchase this compound for laboratory experiments investigating metabolic pathways or designing novel chemical probes. The availability of this intermediate from reliable chemical manufacturers facilitates broad exploration in life sciences.

Sourcing Considerations: When procuring Boc-L-Leucine Monohydrate, buyers should prioritize manufacturers known for their quality control and consistent production standards. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity intermediates, understanding that the success of your research or product development hinges on the quality of the raw materials. We offer competitive pricing and reliable supply chains, making us an ideal partner for businesses seeking to purchase chemical raw materials from China.

In summary, Boc-L-Leucine Monohydrate is a versatile and essential chemical intermediate. Its well-defined chemical properties and critical role in peptide synthesis and biochemical research make it a sought-after compound. By choosing a reputable supplier that emphasizes purity and provides robust technical support, organizations can confidently advance their projects.