Boc-O-(2-bromo-Cbz)-L-Tyrosine: A Versatile Pharmaceutical Intermediate
The pharmaceutical industry constantly seeks advanced chemical building blocks that can streamline the synthesis of complex drug molecules. Boc-O-(2-bromo-Cbz)-L-Tyrosine, identified by its CAS number 47689-67-8, has emerged as a particularly versatile pharmaceutical intermediate. This protected amino acid derivative offers unique advantages for researchers and manufacturers engaged in drug discovery and development.
Characterized by its white crystalline powder appearance and a high purity assay (typically 98.5% min), Boc-O-(2-bromo-Cbz)-L-Tyrosine is a testament to precise chemical manufacturing. Its structure, featuring the tert-butyloxycarbonyl (Boc) protecting group on the alpha-amino function and the 2-bromo-benzyloxycarbonyl (2-bromo-Cbz) protecting group on the hydroxyl of L-Tyrosine, provides chemists with significant synthetic flexibility. This dual protection scheme allows for selective removal of protecting groups under different reaction conditions, a crucial aspect in multi-step organic syntheses.
The primary application of Boc-O-(2-bromo-Cbz)-L-Tyrosine is in peptide synthesis. Peptides are an increasingly important class of therapeutics, and their synthesis requires protected amino acid building blocks like this one. The 2-bromo-Cbz group offers a distinct cleavage mechanism, distinct from standard Cbz or Boc protection, providing orthogonal protection strategies that are invaluable when constructing complex peptide sequences or when other acid-labile or base-labile groups are present in the molecule. This makes it an excellent choice for researchers aiming to buy high-quality reagents for advanced peptide construction.
For pharmaceutical companies and contract research organizations (CROs), sourcing this intermediate reliably is key. Manufacturers in China are a significant source for these high-purity chemicals. When looking to buy Boc-O-(2-bromo-Cbz)-L-Tyrosine, it is advisable to partner with a supplier that emphasizes quality control, provides detailed product documentation, and offers competitive pricing. A reliable manufacturer ensures that the compound meets the stringent purity requirements necessary for drug synthesis.
The versatility of Boc-O-(2-bromo-Cbz)-L-Tyrosine also extends to its use in the synthesis of small molecule drugs and other biologically active compounds where a modified tyrosine residue is required. Its stable structure and well-defined reactivity make it an attractive intermediate for chemists developing innovative therapeutic agents. Whether for research purposes or larger-scale manufacturing, ensuring a consistent supply from a trusted supplier is paramount.
In conclusion, Boc-O-(2-bromo-Cbz)-L-Tyrosine (CAS 47689-67-8) is a highly versatile pharmaceutical intermediate due to its unique protecting groups and high purity. Its application in peptide synthesis and broader organic chemistry makes it an essential compound for drug discovery. We encourage professionals seeking to buy this valuable intermediate to consider our capabilities as a dedicated manufacturer and supplier, committed to quality and customer satisfaction.
Perspectives & Insights
Chem Catalyst Pro
“5% min), Boc-O-(2-bromo-Cbz)-L-Tyrosine is a testament to precise chemical manufacturing.”
Agile Thinker 7
“Its structure, featuring the tert-butyloxycarbonyl (Boc) protecting group on the alpha-amino function and the 2-bromo-benzyloxycarbonyl (2-bromo-Cbz) protecting group on the hydroxyl of L-Tyrosine, provides chemists with significant synthetic flexibility.”
Logic Spark 24
“This dual protection scheme allows for selective removal of protecting groups under different reaction conditions, a crucial aspect in multi-step organic syntheses.”