In the demanding B2B landscape of pharmaceutical manufacturing, the procurement of high-quality intermediates is a critical determinant of product success. For companies requiring 1-O-Acetyl-2,3,5-Tri-O-Benzoyl-Beta-D-Ribofuranose (CAS: 6974-32-9), a pivotal compound in the synthesis of the anticancer drug Clofarabine, sourcing reliable suppliers is paramount. This article delves into why this intermediate is so vital and what B2B buyers should look for when seeking to purchase it, especially from manufacturers in China.

Why is 1-O-Acetyl-2,3,5-Tri-O-Benzoyl-Beta-D-Ribofuranose Essential?

This specific ribofuranose derivative, with its characteristic benzoyl and acetyl protecting groups, is indispensable for the efficient synthesis of nucleoside analogues. Its high purity, often specified at 99% or greater, ensures that subsequent chemical reactions proceed smoothly, leading to the desired active pharmaceutical ingredient (API) with minimal by-products. Clofarabine, a crucial treatment for pediatric leukemia, relies on this intermediate for its structural integrity and therapeutic effectiveness. Therefore, any compromise in the quality of this starting material directly impacts the final drug product's safety and efficacy.

Key Considerations for B2B Buyers When Purchasing CAS 6974-32-9

For procurement managers and R&D scientists, several factors are crucial when evaluating suppliers of 1-O-Acetyl-2,3,5-Tri-O-Benzoyl-Beta-D-Ribofuranose:

  • Purity and Quality Assurance: Verify that the supplier can consistently provide material meeting the required purity specifications. Look for detailed Certificates of Analysis (CoA) and ensure the supplier adheres to strict quality management systems, such as ISO or GMP.
  • Supply Chain Reliability: The ability to secure a stable and uninterrupted supply is vital for manufacturing schedules. Investigate the supplier's production capacity and track record for on-time delivery.
  • Competitive Pricing and Value: While quality is paramount, cost-effectiveness is also a significant consideration. Compare quotes from multiple reputable manufacturers to secure the best possible price without sacrificing quality. Understanding the price per kilogram is essential for budgeting.
  • Technical Support and Documentation: A responsive supplier who can provide technical data, MSDS, and assist with regulatory inquiries adds significant value.

Navigating the Chinese Market for Pharmaceutical Intermediates

China is a global leader in the production of chemical intermediates. For 1-O-Acetyl-2,3,5-Tri-O-Benzoyl-Beta-D-Ribofuranose, sourcing from established Chinese manufacturers can offer a competitive advantage. It is essential to perform due diligence, ensuring the chosen manufacturer has a proven history of quality and reliability in the international pharmaceutical supply chain. Engaging directly with manufacturers or their authorized distributors is often the most efficient way to secure pricing and understand lead times.

In conclusion, for businesses needing to purchase this critical pharmaceutical intermediate, a strategic approach to supplier selection, prioritizing quality, reliability, and value, is key. By understanding the importance of 1-O-Acetyl-2,3,5-Tri-O-Benzoyl-Beta-D-Ribofuranose (CAS: 6974-32-9) and vetting suppliers rigorously, companies can ensure the success of their pharmaceutical manufacturing operations.