For researchers in the pharmaceutical and chemical sciences, access to high-quality building blocks is fundamental to driving innovation. Pyrrolo[2,3-d]pyrimidin-4-ol, identified by CAS number 3680-71-5, is one such compound. Its utility as a pharmaceutical intermediate, particularly in the synthesis of Ruxolitinib Phosphate, makes it a sought-after material for research and development (R&D) projects. This guide provides insights for scientists looking to buy Pyrrolo[2,3-d]pyrimidin-4-ol for their laboratory needs.

Understanding the Research Applications of Pyrrolo[2,3-d]pyrimidin-4-ol

Pyrrolo[2,3-d]pyrimidin-4-ol is a versatile molecule used in various R&D capacities:

  • Drug Discovery and Synthesis: Its primary role is as an intermediate in the synthesis of APIs. Researchers use it to build complex molecular structures, exploring new drug candidates or optimizing synthesis routes for known pharmaceuticals. The specific role in Ruxolitinib synthesis makes it a target for studies in JAK inhibitor development.
  • Medicinal Chemistry Research: The heterocyclic scaffold of Pyrrolo[2,3-d]pyrimidin-4-ol makes it an attractive starting point for creating novel compounds with potential biological activities. Medicinal chemists can modify its structure to explore structure-activity relationships (SARs).
  • Process Development Studies: For pharmaceutical companies developing or scaling up the production of Ruxolitinib, Pyrrolo[2,3-d]pyrimidin-4-ol is essential for optimizing reaction conditions, yields, and purification methods.
  • Analytical Standards and Impurity Profiling: In some cases, highly purified Pyrrolo[2,3-d]pyrimidin-4-ol might be used as a reference standard for analytical testing of related compounds or as a reference for potential impurities in larger synthesis projects.

Key Considerations When Buying for R&D

When researchers need to buy Pyrrolo[2,3-d]pyrimidin-4-ol, several factors are critical:

  • Purity and Quality: While industrial-grade materials might suffice for some applications, R&D often demands high purity (e.g., >98%). Ensure the supplier provides a CoA that confirms the purity and a well-defined impurity profile.
  • Quantity Flexibility: R&D projects typically require smaller quantities, ranging from milligrams to grams. Look for suppliers who cater to these needs and offer flexible packaging options.
  • Supplier Reputation and Responsiveness: Choose suppliers with a good reputation for quality and customer service. Prompt responses to inquiries about product availability, technical data, and shipping are important.
  • Safety Information (MSDS): Always obtain and review the Material Safety Data Sheet (MSDS) before handling the compound. This provides vital information on hazards, safe handling, and emergency procedures.
  • Price vs. Value: While budget is a consideration, prioritize value. The cost of a small quantity of high-purity Pyrrolo[2,3-d]pyrimidin-4-ol from a reliable source is often more cost-effective in the long run than dealing with the consequences of using a substandard material.

Where to Buy Pyrrolo[2,3-d]pyrimidin-4-ol

Specialized chemical suppliers and manufacturers are the primary sources for Pyrrolo[2,3-d]pyrimidin-4-ol. Many manufacturers, including those in China, offer research-grade quantities. When searching to buy, look for online catalogs that provide detailed product specifications and easy ordering processes. Partnering with a supplier that understands the needs of researchers can streamline your procurement.

In conclusion, buying Pyrrolo[2,3-d]pyrimidin-4-ol for research and development requires careful attention to purity, quantity, and supplier reliability. By making informed choices, scientists can ensure they have the essential tools to advance their critical research objectives.