For pharmaceutical companies engaged in the synthesis of vital medications, the procurement of key intermediates like (R)-3-Piperidinamine Dihydrochloride (CAS 334618-23-4) is a strategic undertaking. This chiral compound is indispensable in the manufacturing of Alogliptin, a crucial drug for managing Type 2 diabetes. When planning to buy this pharmaceutical intermediate, understanding the factors influencing its price, the critical importance of purity, and effective sourcing strategies will ensure an efficient and successful procurement process.

Understanding Pricing Factors: Beyond the Per Kilogram Rate

The price of (R)-3-Piperidinamine Dihydrochloride is influenced by several factors, making a direct per-kilogram comparison sometimes insufficient. Key elements include:

  • Purity Level: Higher purity grades (e.g., ≥98% or higher enantiomeric excess) command higher prices due to more complex synthesis and purification processes.
  • Order Volume: Bulk purchases typically result in lower per-unit costs. Manufacturers often offer tiered pricing based on quantity.
  • Manufacturing Location and Costs: Production in regions with efficient supply chains and competitive manufacturing costs, such as China, can influence overall pricing.
  • Quality Certifications and Documentation: Suppliers providing comprehensive documentation (COAs, GMP compliance where applicable) may reflect these quality assurance measures in their pricing.
  • Market Demand: Fluctuations in demand for Alogliptin or other drugs utilizing this intermediate can impact pricing.

When requesting quotes, be specific about your purity requirements and expected order volumes to receive accurate pricing.

The Non-Negotiable: Purity and Chiral Integrity

In pharmaceutical synthesis, purity is not just a specification; it’s a fundamental requirement for drug safety and efficacy. For (R)-3-Piperidinamine Dihydrochloride, both chemical purity and enantiomeric purity (chiral integrity) are critical. The (R) configuration is essential for its role in creating the biologically active form of Alogliptin. Impurities, including the (S) enantiomer, can lead to reduced efficacy or unintended side effects in the final API. Therefore, always prioritize suppliers who can reliably provide material with guaranteed high chemical purity (≥98%) and stereochemical purity, supported by rigorous analytical data (HPLC, chiral HPLC).

Effective Sourcing Strategies

To ensure a stable and cost-effective supply of (R)-3-Piperidinamine Dihydrochloride, consider the following sourcing strategies:

  • Identify Reputable Manufacturers: Focus on established chemical manufacturers and suppliers in China known for their expertise in chiral intermediates and pharmaceutical raw materials.
  • Request Multiple Quotes: Engage with several potential suppliers to compare pricing, lead times, and service offerings.
  • Vet Suppliers Thoroughly: Review their quality management systems, certifications (e.g., ISO), and ask for samples for internal testing before committing to large orders.
  • Build Long-Term Relationships: Establishing a strong partnership with a trusted supplier can lead to better pricing, priority access to stock, and dedicated support.
  • Understand Incoterms: Familiarize yourself with shipping terms like FOB, CFR, or DDP to accurately factor in logistics costs.

As a leading manufacturer and supplier, we are committed to providing the pharmaceutical industry with high-quality (R)-3-Piperidinamine Dihydrochloride at competitive prices. We invite you to contact us to obtain a detailed quote and discuss your specific sourcing needs. Partnering with us means gaining access to a reliable, quality-assured supply chain for this vital pharmaceutical intermediate.