In the complex world of pharmaceutical manufacturing, understanding the critical intermediates that form the backbone of life-saving medications is essential for procurement and R&D professionals. For those involved in the production of Febuxostat, a key treatment for gout and hyperuricemia, the compound identified by CAS number 144060-93-5 – Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate – is of paramount importance. This article explores why this specific intermediate is so crucial and what buyers should consider when looking to purchase it.

Why is CAS 144060-93-5 Critical for Febuxostat?

Febuxostat, a xanthine oxidase inhibitor, is synthesized through a series of chemical reactions, each requiring specific precursor molecules. Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate is one such precursor, often appearing in the earlier stages of the synthetic pathway. Its chemical structure is carefully designed to incorporate essential molecular fragments that will ultimately form the active Febuxostat molecule. The presence of the nitro group, the specific alkoxy substituent, and the thiazole ring system are all vital for the subsequent transformations to yield the desired API with high purity and yield.

Key Considerations for Buyers: Purity, Price, and Supplier Reliability

When seeking to buy CAS 144060-93-5, procurement managers must focus on several key areas:

  • Purity and Specifications: The compound must meet stringent purity standards, typically ≥98.0% assay, to ensure it doesn't introduce unwanted byproducts into the Febuxostat synthesis. The physical form, such as a white to off-white crystalline powder, also matters for handling and reaction consistency.
  • Price Negotiation: Obtaining competitive pricing is crucial for managing production costs. Understanding the market dynamics and engaging with multiple suppliers can help secure favorable terms. When looking for price points, consider sourcing from China, known for its efficient chemical manufacturing capabilities.
  • Supplier Reputation: It is vital to partner with a manufacturer or supplier that has a strong reputation for quality, consistency, and timely delivery. This often involves checking for certifications, customer testimonials, and the ability to provide thorough documentation like Certificates of Analysis (CoA).
  • Supply Chain Stability: Ensuring a stable and uninterrupted supply of this intermediate is critical for maintaining production schedules. Companies should assess the supplier's production capacity and logistical capabilities.

The Advantage of Sourcing from Reputable Manufacturers

As a manufacturer and supplier specializing in pharmaceutical intermediates, we provide Ethyl 2-[4-(2-methylpropoxy)-3-nitrophenyl]-1,3-thiazole-5-carboxylate that meets the exacting standards of the pharmaceutical industry. Our production processes are optimized to ensure high purity and consistent quality batch after batch. We understand the global demand for reliable Febuxostat intermediates and are positioned to serve clients worldwide. By choosing us, you gain access to a dependable supply chain, competitive pricing, and the assurance that your critical raw materials are sourced from a trusted manufacturer in China.

For your procurement needs of CAS 144060-93-5, we invite you to request a quote or contact our sales team. We are committed to being your preferred partner for high-quality pharmaceutical intermediates.