For professionals in the pharmaceutical and chemical industries, understanding the specifications and sourcing strategies for key excipients is crucial. Cellulose Acetate Phthalate (CAP), identified by CAS number 9004-38-0, is a vital material, primarily recognized for its efficacy in enteric coating applications. This guide aims to equip buyers with the knowledge needed to make informed purchasing decisions, focusing on quality, application suitability, and supplier selection, particularly when looking to buy from China.

Cellulose Acetate Phthalate is a polymer synthesized from cellulose, acetylated and then esterified with phthalic acid. Its defining characteristic is its solubility profile: it is resistant to acidic conditions but soluble in alkaline media. This property makes it an ideal coating material for oral dosage forms that need to bypass the stomach and release their active ingredients in the small intestine. This protects acid-labile drugs and prevents gastrointestinal irritation.

When considering the purchase of CAP, several quality parameters are of utmost importance. Buyers should always inquire about the following:

  • Purity: Ensure the CAP meets pharmacopoeial standards (e.g., USP, EP, JP) if intended for pharmaceutical use. High purity minimizes the risk of adverse reactions or interactions with the API.
  • Degree of Substitution (DS): This value indicates the extent of phthalate esterification and acetyl substitution, directly influencing the coating's dissolution pH and film properties.
  • Viscosity and Molecular Weight: These parameters affect the processing characteristics, such as sprayability and film integrity during the coating process.
  • Appearance: Typically a white to off-white powder, uniformity in appearance is a good indicator of consistent manufacturing.

As a product widely manufactured in China, understanding how to engage with suppliers is key. When requesting a quote for Cellulose Acetate Phthalate, be specific about your required quantity, purity grade, and any special packaging needs. A reputable manufacturer will provide a detailed Certificate of Analysis (CoA) for each batch, confirming adherence to specifications. It's also beneficial to inquire about their production capacity, quality management systems (e.g., ISO certification), and lead times.

The applications of CAP are predominantly in pharmaceuticals, but its unique properties can also be leveraged in other areas requiring pH-controlled release or protection. For researchers and product developers, CAP represents a reliable and cost-effective solution for creating sophisticated dosage forms. The ability to buy CAP in bulk from a direct manufacturer in China can offer significant cost advantages, provided quality is not compromised.

In essence, a successful procurement of Cellulose Acetate Phthalate hinges on diligence. By understanding the material's critical parameters and thoroughly vetting potential suppliers, pharmaceutical professionals can secure a high-quality excipient that contributes to the development of safe and effective medicines. Engaging with experienced chemical suppliers who can provide both the product and the necessary technical support is a strategic advantage in today's competitive market.