In the complex world of pharmaceutical manufacturing, the precise chemical composition and quality of intermediates are as crucial as the final API itself. 4-(methylamino)-3-nitrobenzoyl chloride, identified by CAS number 82357-48-0, stands as a testament to this principle, playing a pivotal role in the synthesis of potent anticoagulant drugs like Dabigatran Etexilate. Understanding its chemical identity and applications is key for professionals in the field.

This organic compound is characterized by its molecular formula C8H7ClN2O3 and a molecular weight of 214.606 g/mol. Typically presented as a white powder, its reactivity as a benzoyl chloride derivative makes it an ideal candidate for specific coupling reactions in organic synthesis. The stringent quality requirements for this intermediate, often demanding an assay of ≥98.0%, underscore its importance in ensuring the efficacy and safety of the final pharmaceutical product. Its physical properties, such as a density of approximately 1.5 g/cm³ and a boiling point of around 353.3 °C at 760 mmHg, are also important considerations for handling and process design.

The primary pharmaceutical application of 4-(methylamino)-3-nitrobenzoyl chloride lies in its role as a key precursor for Dabigatran Etexilate (CAS: 211915-06-9) and its mesylate salt (CAS: 872728-81-9). These medications are vital in preventing blood clots, thereby reducing the risk of stroke and other thromboembolic events. For pharmaceutical companies and researchers, accessing this intermediate reliably is essential for both large-scale manufacturing and ongoing R&D efforts. This necessitates partnering with dependable chemical manufacturers, particularly those with a strong presence in regions like China, known for their robust chemical production capabilities.

When engaging with a supplier for 4-(methylamino)-3-nitrobenzoyl chloride, buyers often look for comprehensive specifications, competitive pricing, and evidence of robust quality control measures. The ability to secure this intermediate through a straightforward purchase process, with options for wholesale quantities, streamlines the procurement workflow. Moreover, a good supplier will often provide essential technical data and support, aiding in the integration of the intermediate into complex synthetic routes.

In summary, 4-(methylamino)-3-nitrobenzoyl chloride is more than just a chemical name and CAS number; it is a critical chemical backbone that supports the production of essential medicines. For professionals in the pharmaceutical industry, understanding its properties and the importance of reliable sourcing from qualified manufacturers is fundamental to advancing healthcare solutions.