Navigating the vast landscape of chemical intermediates can be challenging, but understanding the properties and applications of key compounds is essential for innovation. Ethyl 2-Fluoropropionate (CAS: 349-43-9) is one such intermediate that holds significant value across multiple industries, particularly in pharmaceuticals and agrochemicals. NINGBO INNO PHARMCHEM CO., LTD., a leading supplier of specialty chemicals, is pleased to offer insights into this versatile fluorinated compound.

Ethyl 2-Fluoropropionate is an organic ester characterized by the chemical formula C5H9FO2 and a molecular weight of approximately 120.12 g/mol. It presents as a clear, colorless to light yellow liquid, possessing a boiling point of 125°C and a flash point of 29°C, indicating it is a flammable liquid that requires careful handling. Its density is around 0.997 g/mL, and its refractive index is approximately 1.375-1.379. These physical properties are important for formulators and chemists when designing reaction conditions and handling procedures.

The significance of Ethyl 2-Fluoropropionate lies in its role as a fluorinated building block. The strategic introduction of a fluorine atom into organic molecules can dramatically alter their physicochemical and biological properties. In pharmaceuticals, this often leads to enhanced metabolic stability, increased lipophilicity, improved target binding affinity, and better oral bioavailability. For instance, it is utilized in the synthesis of specific nicotinic acid receptor agonists, important in treating conditions like dyslipidemia. Similarly, in agrochemical development, the fluorine moiety contributes to greater efficacy and improved environmental persistence for pesticides and herbicides, ensuring more effective crop protection.

The synthesis of Ethyl 2-Fluoropropionate typically involves the fluorination of ethyl 2-chloropropionate using potassium fluoride in a suitable solvent like DMF, often in the presence of a phase transfer catalyst such as tetrabutylammonium bromide. Achieving high purity, as demonstrated by a 99.5% yield in reference synthesis, is a testament to refined chemical processes, which we replicate and optimize at NINGBO INNO PHARMCHEM. Our commitment as a manufacturer is to provide a reliable source of this high-purity intermediate, meeting the exacting standards of industries that depend on it.

For companies seeking to buy Ethyl 2-Fluoropropionate, understanding its properties and applications empowers better procurement decisions. As your trusted supplier, NINGBO INNO PHARMCHEM CO., LTD. ensures consistent quality and competitive pricing, supported by excellent customer service. We invite you to explore how our high-quality Ethyl 2-Fluoropropionate can be the cornerstone of your next successful synthesis project.