In the realm of pharmaceutical synthesis, certain chemical intermediates stand out due to their indispensable roles in creating life-saving medications. One such compound is 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine. This article delves into the specifics of this important molecule, detailing its properties, synthesis relevance, and why sourcing it from a reliable manufacturer is crucial for the pharmaceutical industry.

Chemically known as N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide, this compound features a complex structure derived from a pyrimidine core. Its molecular formula, C16H19BrFN3O2S, and molecular weight of 416.30800 provide essential data points for chemists. The physical and chemical properties are critical for its handling and application. Typically, it presents as a white to off-white powder, a common characteristic for many high-purity organic synthesis intermediates. Its purity is generally specified at ≥98.0%, with stringent controls on single impurities (≤1.0%) and loss on drying (≤0.5%), ensuring consistent performance in pharmaceutical manufacturing.

The primary application of 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine is its function as a key intermediate in the synthesis of Rosuvastatin Calcium. Rosuvastatin is a statin medication widely prescribed to manage hyperlipidemia and reduce the risk of cardiovascular events. The bromomethyl group on this pyrimidine derivative is highly reactive and serves as a crucial handle for subsequent chemical transformations, enabling the assembly of the complete Rosuvastatin molecule. Therefore, for API manufacturers, securing a consistent supply of this high-quality intermediate is a fundamental requirement.

When considering where to buy this chemical, it is imperative to partner with a reputable manufacturer and supplier, particularly those specializing in pharmaceutical intermediates. Factors to evaluate include the supplier's adherence to quality standards, their manufacturing capacity, and their ability to provide thorough documentation. Manufacturers in China have become significant global suppliers due to their advanced synthesis capabilities and competitive pricing structures. It's important to request comprehensive CoAs and consider the supplier's experience in handling and storing such reactive compounds, ensuring they are kept in a cool, dry, and well-ventilated area in tightly closed containers.

The strategic importance of 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine in the production of a major pharmaceutical agent underscores the need for a reliable and quality-focused supply chain. By understanding its chemical properties and applications, pharmaceutical professionals can make informed decisions when sourcing this vital building block. We are committed to being that trusted supplier, providing high-purity intermediates that meet the exacting standards of the pharmaceutical industry.