In the complex world of chemical synthesis, intermediate compounds act as crucial stepping stones, bridging raw materials to final, high-value products. 2-Bromo-5-fluoro-isonicotinonitrile, identified by CAS number 1256822-16-8, is one such pivotal intermediate, particularly valued in the pharmaceutical and fine chemical industries. Understanding its properties, applications, and sourcing considerations is essential for researchers and procurement specialists alike.

Chemical Structure and Properties

2-Bromo-5-fluoro-isonicotinonitrile is a derivative of isonicotinonitrile, which is pyridine-4-carbonitrile. Its chemical structure (C6H2BrFN2) features a pyridine ring substituted with a bromine atom at the 2-position, a fluorine atom at the 5-position, and a nitrile group at the 4-position. This specific arrangement of functional groups imparts unique reactivity and utility. Typically supplied as a solid, with appearances ranging from white to off-white, its molecular weight is approximately 201 g/mol. A key specification for its use, especially in pharmaceutical applications, is its purity, which is often required to be 97% or higher.

Significance as a Pharmaceutical Intermediate

The pharmaceutical industry extensively utilizes pyridine-based heterocycles as core structures in many drug molecules. The presence of bromine, fluorine, and a nitrile group on the pyridine ring makes 2-Bromo-5-fluoro-isonicotinonitrile a highly versatile building block. The bromine atom serves as a reactive handle for a myriad of coupling reactions (e.g., Suzuki, Sonogashira), allowing for the introduction of diverse substituents. The fluorine atom can modulate pharmacokinetic properties, such as lipophilicity and metabolic stability, which are critical for drug efficacy. The nitrile group can be readily converted into other functional groups like amines or carboxylic acids, adding further synthetic flexibility. Consequently, this intermediate is instrumental in the synthesis of novel APIs and advanced pharmaceutical compounds.

Applications in Fine Chemicals and Research

Beyond pharmaceuticals, 2-Bromo-5-fluoro-isonicotinonitrile finds application in the broader fine chemical sector. Its well-defined reactivity allows for its use in synthesizing specialized organic compounds for materials science, agrochemicals, and other advanced research areas. Researchers often search for this compound by its CAS number to ensure they are obtaining the correct material with the necessary purity for their specific experimental needs. When planning to buy this intermediate, it is crucial to work with suppliers who can guarantee consistent quality and provide detailed product specifications.

Sourcing and Quality Assurance

Procuring 2-Bromo-5-fluoro-isonicotinonitrile, especially in larger quantities for research or production, requires partnering with reliable manufacturers and suppliers. Companies specializing in pharmaceutical intermediates, such as NINGBO INNO PHARMCHEM CO.,LTD., play a vital role in the supply chain. They ensure that the product meets stringent quality standards, offering products with high purity and comprehensive documentation like Certificates of Analysis. For any scientist or procurement manager, identifying a trustworthy source that can provide this essential intermediate with consistent quality and competitive pricing is a fundamental step towards successful chemical synthesis and product development.