The advancement of neuroscience research hinges on the availability of precise and high-quality chemical tools. These molecules serve as probes, modulators, and building blocks for understanding the intricate mechanisms of the brain. Among these essential tools are specialized chemical intermediates that enable the synthesis of novel compounds targeting specific neurological pathways.

One such critical intermediate is the trifluoromethyl pyrazole derivative, 1H-Pyrazole-1-acetamide, N-[3-(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]-5-methyl-3-(trifluoromethyl)-, identified by CAS number 489408-02-8. This compound, often known as HBT1, plays a significant role in research related to AMPA receptors. AMPA receptors are fundamental to excitatory neurotransmission and are deeply implicated in processes such as learning, memory, and synaptic plasticity.

HBT1 is recognized as an AMPA receptor potentiator, meaning it can enhance the signaling of these receptors. This property makes it invaluable for researchers investigating conditions where AMPA receptor function may be impaired, or for exploring methods to boost cognitive functions. Moreover, HBT1 has been linked to the induction of brain-derived neurotrophic factor (BDNF), a protein essential for neuronal health and survival. This dual action—enhancing receptor activity and promoting neurotrophic support—positions HBT1 as a compound of significant interest for therapeutic development in neurological and psychiatric disorders.

For scientists engaged in drug discovery or fundamental neuroscience research, securing a reliable supply of high-purity chemical intermediates like HBT1 is paramount. Purity ensures that experimental outcomes are accurate and reproducible. Therefore, sourcing from reputable manufacturers and suppliers who provide detailed specifications and quality assurance is crucial. Many research chemical providers offer such specialized intermediates, often with competitive pricing for bulk purchases.

The demand for effective treatments for neurodegenerative diseases and cognitive disorders continues to grow, driving innovation in the discovery of molecules that can modulate neural circuits. Intermediates like HBT1 provide the foundational structure for creating more complex molecules with tailored pharmacological profiles. Whether for in vitro assays, cellular studies, or early-stage preclinical research, having a dependable source for these materials is key.

If your research focus lies within cognitive neuroscience, neuropharmacology, or the development of novel therapeutics for brain health, understanding and utilizing specialized chemical intermediates is indispensable. We, as a dedicated supplier of high-quality chemical compounds, are committed to supporting the scientific community. If you are looking to buy HBT1 or other critical intermediates for your neuroscience research, please contact us to learn more about our product offerings, pricing, and reliable supply capabilities.