For chemists and formulators, a thorough understanding of a chemical intermediate's properties is fundamental to its effective and safe utilization. 3-Pyridyl Bromide (CAS No.: 626-55-1) is a versatile organic compound with a specific set of characteristics that dictate its applications and handling procedures. This article delves into the key chemical and physical properties of 3-Pyridyl Bromide, providing valuable insights for professionals in the field.

The most commonly cited appearance for 3-Pyridyl Bromide is a clear, colorless to yellow liquid. While some sources might mention it as a white powder, the liquid form is more typical for commercial supply, often with a specific gravity around 1.64 g/mL at 25°C. Its molecular formula is C5H4BrN, with a molecular weight of approximately 158.00 g/mol. The boiling point is consistently reported around 173°C, a critical parameter for processes involving distillation or high-temperature reactions. These physical properties, alongside its solubility (e.g., 31g/L in water at 20°C), are vital for process design and optimization.

From a chemical reactivity standpoint, 3-Pyridyl Bromide is an electrophilic aromatic compound. The bromine atom attached to the pyridine ring makes it susceptible to nucleophilic substitution reactions and a prime candidate for various organometallic coupling reactions, such as Suzuki, Stille, and Sonogashira couplings. These reactions are foundational in building more complex molecular architectures, particularly relevant in pharmaceutical synthesis and the creation of advanced materials. Understanding its pKa (around 2.84 at 25°C) also provides insights into its behavior in acidic or basic environments.

Safety considerations are paramount when handling any chemical. 3-Pyridyl Bromide is classified as flammable and can be harmful if swallowed, inhaled, or absorbed through the skin. Hazard statements like H226 (Flammable liquid and vapor) and H302 (Harmful if swallowed) highlight the need for appropriate personal protective equipment (PPE), including gloves, eye protection, and adequate ventilation. Storage recommendations typically include keeping the container tightly closed in a ventilated, cool, and dry warehouse, away from sources of ignition and incompatible materials like strong oxidizing agents. Proper handling and storage ensure product integrity and workplace safety.

For businesses looking to purchase 3-Pyridyl Bromide, selecting a supplier that adheres to high standards of product quality and provides comprehensive safety data is essential. As a dedicated manufacturer and supplier, we ensure that our 3-Pyridyl Bromide meets rigorous specifications. We encourage all users to consult the Material Safety Data Sheet (MSDS) before handling and to follow all recommended safety protocols. By understanding these properties, professionals can confidently integrate 3-Pyridyl Bromide into their synthetic strategies.