For professionals in the chemical and pharmaceutical industries, a thorough understanding of chemical compounds is essential for innovation and development. This article provides a focused look at 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene (CAS: 1034305-17-3), detailing its chemical profile, synthesis considerations, and its importance as a versatile intermediate. We aim to equip researchers and procurement specialists with the knowledge needed to effectively source and utilize this compound.

Chemical Identity and Core Properties

The compound 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene possesses a molecular formula of C15H10BrFS and a molecular weight of approximately 321.21 g/mol. Its CAS number, 1034305-17-3, serves as its unique identifier in global chemical databases. Physically, it is typically classified as a solid, often appearing as a white to off-white powder or crystalline substance. Key physicochemical properties include a predicted boiling point of around 408.9±35.0 °C and a density of roughly 1.509±0.06 g/cm³. These properties are critical for handling, storage, and reaction planning. Manufacturers usually maintain a purity standard of 97% or higher, ensuring its suitability for sensitive chemical processes.

Synthesis Pathways and Raw Materials

The synthesis of 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene often originates from simpler benzo[b]thiophene precursors. A representative synthetic route involves the reduction of an intermediate alcohol, such as benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol. This transformation typically employs reducing agents like triethylsilane in the presence of a Lewis acid, such as boron trifluoride diethyl etherate, in solvents like dichloromethane. The subsequent purification via column chromatography is vital for achieving the high purity required by the industry. Understanding these synthesis steps helps in appreciating the manufacturing process and the potential for sourcing from specialized chemical producers.

Importance as a Pharmaceutical Intermediate

The primary utility of 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene lies in its role as a pharmaceutical intermediate. Its complex structure, featuring halogenated aromatic rings and the benzo[b]thiophene scaffold, makes it a valuable building block for synthesizing various active pharmaceutical ingredients (APIs). Its documented use as an intermediate in the synthesis of drugs like Ipragliflozin highlights its significance in modern medicinal chemistry. For researchers looking to buy this compound for drug discovery or process development, a reliable supply from manufacturers is essential.

Procurement and Supplier Considerations

When sourcing 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene, professionals should engage with reputable chemical suppliers. Manufacturers, particularly those based in China, often provide this compound with detailed technical specifications and competitive pricing for bulk orders. Prioritizing suppliers who offer consistent quality, reliable delivery, and comprehensive documentation like Certificates of Analysis (CoA) is crucial. Direct inquiries for quotes and samples can help establish a dependable sourcing relationship, ensuring the availability of this important chemical building block for your ongoing projects.

By understanding the chemical profile and synthesis of 2-[(5-bromo-2-fluorophenyl)methyl]-benzo[b]thiophene, professionals can make informed decisions to drive their research and development efforts forward.