For professionals in the pharmaceutical and fine chemical industries, a thorough understanding of chemical intermediates is crucial for successful research, development, and manufacturing. 2-Nitro-4-Bromo-5-fluorobenzoic Acid, with its unique CAS registry number 1020717-99-0, stands out as a significant compound, primarily recognized for its role in synthesizing advanced pharmaceuticals. This article aims to provide an in-depth look at its chemical profile, properties, and essential applications.

Chemically, 2-Nitro-4-Bromo-5-fluorobenzoic Acid is an aromatic carboxylic acid derivative. Its molecular formula is C7H3BrFNO4, and it has a molecular weight of approximately 264.01 g/mol. The molecule features a benzoic acid core substituted with a nitro group (-NO2) at the 2-position, a bromine atom (-Br) at the 4-position, and a fluorine atom (-F) at the 5-position. These functional groups impart specific reactivity, making it a valuable building block in organic synthesis.

Key physical properties often reported for this compound include its appearance, which is typically an off-white crystalline powder. It possesses a predicted boiling point of around 367.6±42.0 °C and a density of approximately 1.967±0.06 g/cm³. The compound is generally stored at room temperature in a dry, sealed environment to maintain its integrity. Its acidity (pKa) is predicted to be around 1.68±0.25.

From a safety perspective, 2-Nitro-4-Bromo-5-fluorobenzoic Acid is classified with warning signals, including hazards related to skin irritation, serious eye irritation, and potential respiratory irritation (H315, H319, H335). Standard precautionary statements advise avoiding inhalation of dust/fume/gas/mist/vapors/spray and recommend wearing protective gloves, clothing, and eye/face protection. Safe handling procedures and adherence to material safety data sheets (MSDS) are essential when working with this chemical.

The primary application of 2-Nitro-4-Bromo-5-fluorobenzoic Acid is its use as a critical intermediate in the synthesis of fluoroquinolone antibiotics. These antibiotics are vital in modern medicine for treating bacterial infections. The specific structural features of this intermediate allow for the introduction of the fluoroquinolone core structure, which is essential for the antibacterial efficacy of drugs like ciprofloxacin. Beyond pharmaceuticals, it can also serve as a valuable building block in other areas of organic synthesis, contributing to the development of novel compounds and materials.

For procurement specialists and research scientists, understanding these properties is key to efficiently sourcing and utilizing this intermediate. When you need to buy 2-Nitro-4-Bromo-5-fluorobenzoic Acid, looking for suppliers who provide detailed specifications, safety data, and consistent quality is a best practice. The availability of this compound from reputable manufacturers, particularly those specializing in pharmaceutical intermediates, ensures that research and production can proceed without interruption.