In the realm of pharmaceutical synthesis, a deep understanding of the chemical and physical properties of intermediates is fundamental. 2-Thioadenosine (CAS 43157-50-2) is a prime example of such a critical compound, serving as a key building block in the creation of vital medications. As a dedicated manufacturer and supplier of specialized chemicals, NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of these properties for our clients.

Physical Characteristics and Appearance

2-Thioadenosine is typically described as a pale yellow to yellow solid. This appearance is consistent across various high-purity grades offered by reputable suppliers. The solid form is advantageous for handling, storage, and precise weighing during complex synthesis procedures. Understanding its physical state is the first step for any procurement manager or research scientist evaluating this compound for their projects.

Key Chemical Properties for Synthesis

The chemical profile of 2-Thioadenosine is characterized by several key parameters relevant to its use as a pharmaceutical intermediate:

  • Melting Point: Reports indicate a melting point exceeding 178°C with decomposition. This signifies a stable compound under normal handling conditions but also highlights the need for care during high-temperature reactions.
  • Solubility: 2-Thioadenosine exhibits limited solubility in water, but is generally soluble in solvents like DMSO and slightly soluble in methanol, particularly when heated or sonicated. This solubility profile is critical for designing reaction conditions and purification processes. Choosing the right solvent system is key when you buy 2-Thioadenosine for your synthesis.
  • pKa: The predicted pKa value is around 8.37 ± 0.40, indicating its potential to act as a weak base, which can influence its behavior in buffered solutions or during specific chemical transformations.
  • Storage Conditions: To maintain its integrity, 2-Thioadenosine should be stored in a cool, dry place, sealed, and protected from light, typically at temperatures between 2-8°C. Proper storage is crucial for preserving the quality obtained from a reliable manufacturer in China.

Molecular Structure and Its Significance

The molecular formula of 2-Thioadenosine is C10H13N5O4S, with a molecular weight of 299.31 g/mol. Its structure, featuring a sulfur atom at the 2-position of the adenosine purine ring, is central to its reactivity and its role as a precursor for drugs like Cangrelor, a P2Y12 inhibitor. This specific structural feature is what allows for the precise chemical modifications required in multi-step pharmaceutical synthesis.

Why Sourcing from NINGBO INNO PHARMCHEM Matters

As a leading supplier of pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. ensures that our 2-Thioadenosine is produced and handled with the utmost care, adhering to strict quality standards. By understanding the critical chemical properties, our clients can confidently integrate our product into their manufacturing processes. We offer detailed specifications and can provide samples for your evaluation. If you are looking to purchase 2-Thioadenosine, our expertise and commitment to quality make us an ideal partner.

The detailed chemical profile of 2-Thioadenosine underscores its importance in pharmaceutical development. By partnering with a trusted manufacturer like NINGBO INNO PHARMCHEM, you gain access to a high-quality intermediate backed by a thorough understanding of its chemical attributes, ensuring the success of your product development pipeline.