For chemists and material scientists, a deep understanding of a compound's chemical profile is the foundation for successful synthesis and application. 2-(Trifluoromethyl)benzaldehyde (CAS 447-61-0) is a molecule of significant interest due to its unique combination of an aldehyde functional group and a trifluoromethyl-substituted aromatic ring. As a leading manufacturer and supplier of specialized chemical intermediates, we offer insights into the properties and synthetic utility of this valuable compound.

Molecular Structure and Identity:

2-(Trifluoromethyl)benzaldehyde has the molecular formula C8H5F3O and a molecular weight of 174.12 g/mol. Its CAS number, 447-61-0, uniquely identifies it in chemical databases. The structure features a benzene ring with an aldehyde group (-CHO) and a trifluoromethyl group (-CF3) positioned ortho to each other. This specific arrangement dictates its chemical behavior and reactivity.

Physical and Chemical Properties:

  • Appearance: Typically described as a colorless to pale yellow clear liquid.
  • Density: Approximately 1.32 g/mL at 25 °C.
  • Melting Point: Reported around -40 °C, indicating it remains liquid at standard room temperatures.
  • Boiling Point: Approximately 70-71 °C at 16 mmHg, suggesting it is a relatively volatile liquid under reduced pressure.
  • Flash Point: Around 142 °F (61 °C), classifying it as a combustible liquid.
  • Refractive Index: n20/D ≈ 1.466, a useful parameter for identification and purity checks.

The trifluoromethyl group is highly electronegative, significantly influencing the electron distribution within the aromatic ring and activating the aldehyde group towards nucleophilic attack. This electronic effect can also impact the regioselectivity of electrophilic aromatic substitution reactions on the ring, although the aldehyde group itself is deactivating.

Synthetic Applications and Reactivity:

The dual functionality of 2-(Trifluoromethyl)benzaldehyde makes it a versatile synthetic intermediate. The aldehyde group readily undergoes reactions such as:

  • Nucleophilic Additions: Reactions with Grignard reagents or organolithium compounds to form secondary alcohols.
  • Condensation Reactions: Such as Wittig or Horner-Wadsworth-Emmons reactions to form alkenes.
  • Oxidation: To form the corresponding carboxylic acid, 2-(Trifluoromethyl)benzoic acid.
  • Reduction: To form the primary alcohol, 2-(Trifluoromethyl)benzyl alcohol.

These reactions are fundamental in building more complex organic molecules, finding extensive use in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. When you need to buy 2-(Trifluoromethyl)benzaldehyde, sourcing from a reliable manufacturer in China ensures you receive a product with consistent properties crucial for reproducible synthetic outcomes.

Understanding these properties is key for chemists planning synthesis strategies. For procurement, knowing these details helps in evaluating potential suppliers and ensuring product suitability. Our commitment as a manufacturer is to provide not just the chemical, but also the assurance of quality and consistency essential for your research and industrial needs.